Trial reportNeurology2010
Cortical neuroanatomic correlates of symptom severity in primary progressive aphasia.
Trial report in Neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- The Neurofunctional Correlates of Morphosyntactic and Thematic Impairments in Aphasia: A Systematic Review and Meta-analysis.Neuropsychology review · 2025Pooled it
- Language and behavior domains enhance the value of the clinical dementia rating scale.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2011Trial
- The Heterogeneity of Reading and Spelling Deficits in Posterior Cortical Atrophy.Brain sciences · 2025Article
- Quality of Assessment Tools for Aphasia: A Systematic Review.Brain sciences · 2025Review
- Distinct neural correlates of morphosyntactic and thematic comprehension processes in aphasia.Brain communications · 2025Article
- Lesion-symptom Mapping of Acceptability Judgments in Chronic Poststroke Aphasia Reveals the Neurobiological Underpinnings of Receptive Syntax.Journal of cognitive neuroscience · 2024Article
- Auditory naming is impaired in posterior cortical atrophy and early-onset Alzheimer's disease.Frontiers in neuroscience · 2024Article
- Grammatical Parallelism in Aphasia: A Lesion-Symptom Mapping Study.Neurobiology of language (Cambridge, Mass.) · 2023Article
- The Wernicke conundrum revisited: evidence from connectome-based lesion-symptom mapping.Brain : a journal of neurology · 2022Article
- Acoustic and Kinematic Assessment of Motor Speech Impairment in Patients With Suspected Four-Repeat Tauopathies.Journal of speech, language, and hearing research : JSLHR · 2022Article
- Verbal Encoding Deficits Impact Recognition Memory in Atypical "Non-Amnestic" Alzheimer's Disease.Brain sciences · 2022Article
- Italian translation and cross-cultural adaptation of the Progressive Aphasia Severity Scale.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Cortical neuroanatomical changes related to specific language impairments in primary progressive aphasia.Frontiers in aging neuroscience · 2022Article
- Longitudinal Changes in Cognition, Behaviours, and Functional Abilities in the Three Main Variants of Primary Progressive Aphasia: A Literature Review.Brain sciences · 2021Review
- Neuroimaging in Frontotemporal Lobar Degeneration: Research and Clinical Utility.Advances in experimental medicine and biology · 2021Review
- Neural substrates of verbal repetition deficits in primary progressive aphasia.Brain communications · 2021Article
- The Cortical Organization of Syntax.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Agrammatism and Paragrammatism: A Cortical Double Dissociation Revealed by Lesion-Symptom Mapping.Neurobiology of language (Cambridge, Mass.) · 2020Article
- Altered functional connectivity of cortical networks in semantic variant Primary Progressive Aphasia.NeuroImage. Clinical · 2020Article
- Quantification of motor speech impairment and its anatomic basis in primary progressive aphasia.Neurology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo test the validity and reliability of a new measure of clinical impairment in primary progressive aphasia (PPA), the Progressive Aphasia Severity Scale (PASS), and to investigate relationships with MRI-based cortical thickness biomarkers for localizing and quantifying the severity of anatomic abnormalities.
methodsPatients with PPA were rated using the PASS and underwent performance-based language testing and MRI scans that were processed for cortical thickness measures.
resultsThe level of impairment in PASS fluency, syntax/grammar, and word comprehension showed strong specific correlations with performance-based measures of these domains of language, and demonstrated high interrater reliability. Left inferior frontal thinning correlated with impairment in fluency and grammar/syntax, while left temporopolar thinning correlated with impairment in word comprehension. Discriminant function analysis demonstrated that a combination of left inferior frontal, left temporopolar, and left superior temporal sulcal thickness separated the 3 PPA subtypes from each other with 100% accuracy (87% accuracy in a leave-one-out analysis).
conclusionsThe PASS, a novel measure of the severity of clinical impairment within domains of language typically affected in PPA, demonstrates reliable and valid clinical-behavioral properties. Furthermore, the presence of impairment in individual PASS domains demonstrates specific relationships with focal abnormalities in particular brain regions and the severity of impairment is strongly related to the severity of anatomic abnormality within the relevant brain region. These anatomic imaging biomarkers perform well in classifying PPA subtypes. These data provide robust support for the value of this novel clinical measure and the new imaging measure as markers for potential use in clinical research and trials in PPA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.