ArticleBlood2010
Essential role for focal adhesion kinase in regulating stress hematopoiesis.
Article in Blood, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 30 citations in OpenAlex.
- ReducedInternational journal of molecular sciences · 2026Article
- Loss of Dnmt3a impairs hematopoietic homeostasis and myeloid cell skewing via the PI3Kinase pathway.JCI insight · 2023Article
- TEAD1 Silencing Regulates Cell Proliferation and Resistance to 5-Fluorouracil in Cutaneous Squamous Cell Carcinoma.Clinical, cosmetic and investigational dermatology · 2022Article
- Mast cells mediate early neutrophil recruitment and exhibit anti-inflammatory properties via the formyl peptide receptor 2/lipoxin ABritish journal of pharmacology · 2017Article
- Saponins fromFrontiers in pharmacology · 2017Article
- Hypoxic niche-mediated regeneration of hematopoiesis in the engraftment window is dominantly affected by oxygen tension in the milieu.Stem cells and development · 2015Article
- β-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies.Haematologica · 2015Review
- FAK mediates a compensatory survival signal parallel to PI3K-AKT in PTEN-null T-ALL cells.Cell reports · 2015Article
- Iron age: novel targets for iron overload.Hematology. American Society of Hematology. Education Program · 2014Review
- Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis.Cell reports · 2014Article
- FAK in cancer: mechanistic findings and clinical applications.Nature reviews. Cancer · 2014Review
- β-Thalassemia and Polycythemia vera: targeting chronic stress erythropoiesis.The international journal of biochemistry & cell biology · 2014Review
- Article
- PTK2 and PTPN11 expression in myelodysplastic syndromes.Clinics (Sao Paulo, Brazil) · 2013Article
- Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia.Nature medicine · 2013Article
- Focal adhesion kinase regulates the localization and retention of pro-B cells in bone marrow microenvironments.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53.Blood · 2012Article
- Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion.Experimental hematology · 2012Article
- Cytopenia induction by 5-fluorouracil identifies thrombopoietic mutants in sensitized ENU mutagenesis screens.Experimental hematology · 2012Article
- SWAP-70 regulates erythropoiesis by controlling α4 integrin.Haematologica · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that has been extensively studied in fibroblasts; however its function in hematopoiesis remains an enigma. FAK is thought to be expressed in myeloid and erythroid progenitors, and its expression is enhanced in response to cytokines such as granu-locyte macrophage colony-stimulating factor. Furthermore, bone marrow cells cultured in granulocyte macrophage colony-stimulating factor show active migration and chemoattractant-induced polarization, which correlates with FAK induction. While loss of FAK in mice results in embryonic lethality, we have deleted FAK in the adult bone marrow. We show an essential role for FAK in regulating hemolytic, myelotoxic, as well as acute inflammatory stress responses in vivo. In vitro, loss of FAK in erythroid and myeloid progenitor's results in impaired cytokine induced growth and survival, as well as defects in the activation and expression of antiapoptotic proteins caspase 3 and Bcl-x(L). Additionally, reduced migration and adhesion of myeloid cells on extracellular matrix proteins, as well as impaired activation of Rac GTPase is also observed in the absence of FAK. Our studies reveal an essential role for FAK in integrating growth/survival and adhesion based functions in myeloid and erythroid cells predominantly under conditions of stress.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.