Evidence map›Paper›PMID 20675976›Full record

ReviewPostgraduate medicine2010

Prediabetes: the importance of early identification and intervention.

Willa A Hsueh, Laurie Orloski, Kathleen Wyne

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Postgraduate medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02488057 (Improving Beta Cell Function in Mexican American Women With Prediabetes), which is not on this map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02488057 phase4completedstarted 2016, after this paper: background citation

Improving Beta Cell Function in Mexican American Women With Prediabetes

Ran2016Enrolled360Registered outcomes8Posted comparisons0ConditionsPre-diabetesArmsliraglutide, weight loss
Open the trial in the graph
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 59 citations in OpenAlex.

  1. Trial
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  19. Article
  20. Markers of Sleep-Disordered Breathing and Prediabetes in US Adults.International journal of endocrinology · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Willa A HsuehDiabetes Research Center, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX 77030, USA. wahsueh@tmhs.org
Laurie Orloski
Kathleen Wyne
Bridge Pharma (United States) · USCornell University · USHouston Methodist · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prediabetes is a state of abnormal glucose homeostasis characterized by the presence of impaired fasting glucose, impaired glucose tolerance, or both. Individuals with prediabetes are at increased risk for type 2 diabetes, compared with individuals with normal glucose values (normal fasting plasma glucose, < 100 mg/dL [5.6 mmol/L]). The increased risk for cardiovascular disease in prediabetes is multifactorial, with etiologies including insulin resistance, hyperglycemia, dyslipidemia, hypertension, systemic inflammation, and oxidative stress. The preferred treatment is intensive lifestyle management and aggressive pharmacologic therapies directed toward individual coronary heart disease risk factors. The use of antihyperglycemic agents in this setting is a topic of intense debate. This review discusses the pathophysiology of prediabetes and its clinical implications, highlighting the importance of early identification and intervention.

Indexed as

Angiotensin Receptor AntagonistsBiomarkersBlood GlucoseClinical Trials as TopicDiabetes Mellitus, Type 2Disease ProgressionHumansInsulin ResistanceLife StylePrediabetic StateRisk FactorsRisk Reduction BehaviorAngiotensin Receptor AntagonistsBiomarkersBlood Glucose

Identifiers

PMID20675976
OpenAlexW1971680839

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.