Evidence mapPaperPMID 20718958Full record

ArticleDiabetology & metabolic syndrome2010

Metabolic syndrome, dyslipidemia, hypertension and type 2 diabetes in youth: from diagnosis to treatment.

Alfredo Halpern, Marcio C Mancini, Maria Eliane C Magalhães, Mauro Fisberg, Rosana Radominski, Marcelo C Bertolami, Adriana Bertolami, Maria Edna de Melo, Maria Teresa Zanella, Marcia S Queiroz and 1 more

Registry-linked trialAbstract read
In one paragraph

Article in Diabetology & metabolic syndrome, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06230705 (Community Intervention to impRove CVD Risk Factor controL in Young AmErican Indians), which is not on this map. Cited by 59 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 3 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06230705 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Community Intervention to impRove CVD Risk Factor controL in Young AmErican Indians: The CIRCLE Study

TypeinterventionalSponsorUniversity of OklahomaRan2025 to 2029Enrolled360ConditionsCholesterol, Elevated, Diabetes MellitusArmsGuided management, Self management
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Drug interventions for the treatment of obesity in children and adolescents.The Cochrane database of systematic reviews · 2016
    Pooled it
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  9. Association of Pericardial Fat with Severity of Coronary Artery Disease.The Indian journal of radiology & imaging · 2026
    Article
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  11. Review
  12. Article
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  17. The Constituents ofScientifica · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alfredo HalpernGroup of Obesity and Metabolic Syndrome, Endocrinology and Metabolism Service, Hospital das Clínicas da Faculdade de Medicina, São Paulo University (HC-FMUSP), Av, Dr, Enéas de Carvalho Aguiar, 155 - 8º andar - bloco 3, São Paulo, Brazil. mmancini@usp.br.
Marcio C Mancini
Maria Eliane C Magalhães
Mauro Fisberg
Rosana Radominski
Marcelo C Bertolami
Adriana Bertolami
Maria Edna de Melo
Maria Teresa Zanella
Marcia S Queiroz
Marcia Nery

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Overweight and obesity in youth is a worldwide public health problem. Overweight and obesity in childhood and adolescents have a substantial effect upon many systems, resulting in clinical conditions such as metabolic syndrome, early atherosclerosis, dyslipidemia, hypertension and type 2 diabetes (T2D). Obesity and the type of body fat distribution are still the core aspects of insulin resistance and seem to be the physiopathologic links common to metabolic syndrome, cardiovascular disease and T2D. The earlier the appearance of the clustering of risk factors and the higher the time of exposure, the greater will be the chance of developing coronary disease with a more severe endpoint. The age when the event may occur seems to be related to the presence and aggregation of risk factors throughout life.The treatment in this age-group is non pharmacological and aims at promoting changes in lifestyle. However, pharmacological treatments are indicated in special situations.The major goals in dietary treatments are not only limited to weight loss, but also to an improvement in the quality of life. Modification of risk factors associated to comorbidities, personal satisfaction of the child or adolescent and trying to establish healthy life habits from an early age are also important. There is a continuous debate on the best possible exercise to do, for children or adolescents, in order to lose weight. The prescription of physical activity to children and adolescents requires extensive integrated work among multidisciplinary teams, patients and their families, in order to reach therapeutic success.The most important conclusion drawn from this symposium was that if the growing prevalence of overweight and obesity continues at this pace, the result will be a population of children and adolescents with metabolic syndrome. This would lead to high mortality rates in young adults, changing the current increasing trend of worldwide longevity. Government actions and a better understanding of the causes of this problem must be implemented worldwide, by aiming at the prevention of obesity in children and adolescents.

Identifiers

PMID20718958
PMCPMC2939537

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.