SynthesisAmerican journal of obstetrics and gynecology2010
Oral hypoglycemic agents vs insulin in management of gestational diabetes: a systematic review and metaanalysis.
Synthesis in American journal of obstetrics and gynecology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01998113 (Glyburide and Metformin for the Treatment of Gestational Diabetes Mellitus. A Systematic Review and Meta-analysis of Randomized Controlled Trials Comparing These Drugs Either vs Insulin or vs Each Other.), which is not on this map. Cited by 40 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Glyburide and Metformin for the Treatment of Gestational Diabetes Mellitus. A Systematic Review and Meta-analysis of Randomized Controlled Trials Comparing These Drugs Either vs Insulin or vs Each Other.
Open the trial in the graphWho cites it
40 citing papers in PubMed, 5 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Effectiveness of antidiabetic agents for treatment of gestational diabetes: A methodological quality assessment of meta-analyses and network meta-analysis.Journal of diabetes investigation · 2021Pooled it
- Comparison of glyburide and insulin in the management of gestational diabetes: A meta-analysis.PloS one · 2017Pooled it
- Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis.BMJ (Clinical research ed.) · 2015 · on this mapPooled it
- Efficacy and safety of oral antidiabetic drugs in comparison to insulin in treating gestational diabetes mellitus: a meta-analysis.PloS one · 2014Pooled it
- Metformin vs insulin in the management of gestational diabetes: a meta-analysis.PloS one · 2013 · on this mapPooled it
- Glibenclamide and metfoRmin versus stAndard care in gEstational diabeteS (GRACES): a feasibility open label randomised trial.BMC pregnancy and childbirth · 2017Trial
- Metformin versus Insulin in the Management of Pre-Gestational Diabetes Mellitus in Pregnancy and Gestational Diabetes Mellitus at the Korle Bu Teaching Hospital: A Randomized Clinical Trial.PloS one · 2015 · on this mapTrial
- Gestational diabetes mellitus - more than the eye can see - a warning sign for future maternal health with transgenerational impact.Frontiers in clinical diabetes and healthcare · 2025Review
- Correlates of Insulin Selection as a First-Line Pharmacological Treatment for Gestational Diabetes.American journal of perinatology · 2022Article
- The timing of initiation of pharmacotherapy for women with gestational diabetes mellitus.BMC pregnancy and childbirth · 2020Article
- Progress in the Development of Chitosan Based Insulin Delivery Systems: A Systematic Literature Review.Polymers · 2020Review
- Metformin in Pregnancy Study (MiPS): protocol for a systematic review with individual patient data meta-analysis.BMJ open · 2020Article
- Comparative effects of glibenclamide, metformin and insulin on fetal pancreatic histology and maternal blood glucose in pregnant streptozotocin-induced diabetic rats.African health sciences · 2019Article
- Prevalence and profile of adverse drug reactions in high-risk pregnancy: a cohort study.BMC pregnancy and childbirth · 2019Observational
- Drugs to Control Diabetes During Pregnancy.Clinics in perinatology · 2019Review
- Metformin in the first trimester and risks for specific birth defects in the National Birth Defects Prevention Study.Birth defects research · 2018Article
- Outcomes for Women with Gestational Diabetes Treated with Metformin: A Retrospective, Case-Control Study.Journal of clinical medicine · 2018Article
- Article
- Gestational diabetes from A to Z.World journal of diabetes · 2017Review
- Gestational diabetes mellitus: an updated overview.Journal of endocrinological investigation · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this review was to provide pooled estimates of randomized controlled trials comparing the effects of oral hypoglycemic agents with insulin in achieving glycemic control and to study the maternal and perinatal outcomes in gestational diabetes mellitus. STUDY
designA protocol for the study was developed. All metaanalyses were performed using Stats Direct statistical software (Stats Direct Ltd, Cheshire, UK).
resultsSix studies comprising 1388 subjects were analyzed. No significant differences were found in maternal fasting (weighted mean difference [WMD], 1.31; 95% confidence interval [CI], 0.81-3.43) or postprandial (WMD, 0.80; 95% CI, -3.26 to 4.87) glycemic control. Use of oral hypoglycemic agents (OHAs) was not associated with risk of neonatal hypoglycemia (odds ratio [OR], 1.59; 95% CI, 0.70-3.62), increased birthweight (WMD, 56.11; 95% CI, -42.62 to 154.84), incidence of caesarean section (OR, 0.91; 95% CI, -0.68 to 1.22), or incidence of large-for-gestational-age babies (OR, 1.01; 95% CI, 0.61-1.68).
conclusionOur study demonstrates that there are no differences in glycemic control or pregnancy outcomes when OHAs were compared with insulin.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.