ReviewCardiovascular diabetology2010
Therapies for type 2 diabetes: lowering HbA1c and associated cardiovascular risk factors.
Review in Cardiovascular diabetology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- Effects of a hydroalcoholic extract of Juglans regia (walnut) leaves on blood glucose and major cardiovascular risk factors in type 2 diabetic patients: a double-blind, placebo-controlled clinical trial.BMC complementary and alternative medicine · 2018Trial
- Relationship between hemoglobin A1c and cardiovascular disease in mild-to-moderate hypercholesterolemic Japanese individuals: subanalysis of a large-scale randomized controlled trial.Cardiovascular diabetology · 2011 · on this mapTrial
- The association between glycated hemoglobin levels and in-stent restenosis following percutaneous coronary intervention in coronary artery disease patients.Frontiers in endocrinology · 2026Article
- The effect of different resistance exercise training intensities on cardiovascular risk factors: a systematic review and meta-analysis.European heart journal open · 2025Review
- Article
- Predicting HbA1c Target Achievement in Type 2 Diabetes: A Retrospective Single-Centre Nomogram Derived From National MMC-Standardised Management.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Article
- Expert Panel Guidance and Narrative Review of Treatment Simplification of Complex Insulin Regimens to Improve Outcomes in Type 2 Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2022Review
- Reduced Long-Term Risk of Aortic Aneurysm and Aortic Dissection Among Individuals With Type 2 Diabetes Mellitus: A Nationwide Observational Study.Journal of the American Heart Association · 2018Observational
- Association between Diabetes and Risk of Aortic Dissection: A Case-Control Study in a Chinese Population.PloS one · 2015Article
- Appropriate physical activity and dietary intake achieve optimal metabolic control in older type 2 diabetes patients.Journal of diabetes investigation · 2014Article
- Prescription Practice for Diabetes Management among a Female Population in Primary Health Care.International journal of family medicine · 2014Article
- Antidiabetic Effect of Methanolic Extract from Berberis julianae Schneid. via Activation of AMP-Activated Protein Kinase in Type 2 Diabetic Mice.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Cardiovascular safety profile of currently available diabetic drugs.Ochsner journal · 2014Review
- Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention.International journal of medical sciences · 2014Review
- Sodium glucose co-transport 2 inhibitors in the treatment of type 2 diabetes mellitus: a meta-analysis of randomized double-blind controlled trials.BMC endocrine disorders · 2013Article
- Effect of periodontal treatment on glycemic control of patients with diabetes: A systematic review and meta-analysis.Journal of diabetes investigation · 2013Article
- Glycosylated hemoglobin (HbA1c) levels and clinical outcomes in diabetic patients following coronary artery stenting.Cardiovascular diabetology · 2012Article
- Postprandial hyperglycemia and endothelial function in type 2 diabetes: focus on mitiglinide.Cardiovascular diabetology · 2012Review
- Correlation of magnesium intake with metabolic parameters, depression and physical activity in elderly type 2 diabetes patients: a cross-sectional study.Nutrition journal · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo summarize data supporting the effects of antidiabetes agents on glucose control and cardiovascular risk factors in patients with type 2 diabetes.
methodsStudies reporting on the effects of antidiabetes agents on glycemic control, body weight, lipid levels, and blood pressure parameters are reviewed and summarized for the purpose of selecting optimal therapeutic regimens for patients with type 2 diabetes.
resultsNational guidelines recommend the aggressive management of cardiovascular risk factors in patients with type 2 diabetes, including weight loss and achieving lipid and blood pressure treatment goals. All antidiabetes pharmacotherapies lower glucose; however, effects on cardiovascular risk factors vary greatly among agents. While thiazolidinediones, sulfonylureas, and insulin are associated with weight gain, dipeptidyl peptidase-4 inhibitors are considered weight neutral and metformin can be weight neutral or associated with a small weight loss. Glucagon-like peptide-1 receptor agonists and amylinomimetics (e.g. pramlintide) result in weight loss. Additionally, metformin, thiazolidinediones, insulin, and glucagon-like peptide-1 receptor agonists have demonstrated beneficial effects on lipid and blood pressure parameters.
conclusionManagement of the cardiovascular risk factors experienced by patients with type 2 diabetes requires a multidisciplinary approach with implementation of treatment strategies to achieve not only glycemic goals but to improve and/or correct the underlying cardiovascular risk factors.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.