Evidence map›Paper›PMID 20837645›Full record

Trial reportThe Journal of physiology2010

Training in the fasted state improves glucose tolerance during fat-rich diet.

Karen Van Proeyen, Karolina Szlufcik, Henri Nielens, Koen Pelgrim, Louise Deldicque, Matthijs Hesselink, Paul P Van Veldhoven, Peter Hespel

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 40 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 3 pooled it
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02744183 nacompletednot on this mapstarted 2016, after this paper: background citation

Training in the Fasted State, Glucose Metabolism and Energy Balance

TypeinterventionalSponsorUniversity of BathRan2016 to 2019Enrolled30ConditionsGlucose Metabolism DisordersArmsExercise, Breakfast, Maintain habitual habits
NCT05107583 nacompletednot on this mapstarted 2021, after this paper: background citation

Comparing the Effects of a High- and Low-carbohydrate Pre-exercise Meal Relative to Fasting on Exercise Metabolism, Subsequent Appetite, and Energy Intake in Healthy Males.

TypeinterventionalSponsorNottingham Trent UniversityRan2021 to 2022Enrolled12ConditionsObesity, Metabolic SyndromeArmsLow-Carbohydrate Pre-Exercise Meal, High-Carbohydrate Pre-Exercise Meal, Fasted Exercise
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 102 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Karen Van ProeyenResearch Centre for Exercise and Health, Department of Biomedical Kinesiology, K.U. Leuven, Leuven, Belgium.
Karolina Szlufcik
Henri Nielens
Koen Pelgrim
Louise Deldicque
Matthijs Hesselink
Paul P Van Veldhoven
Peter Hespel
KU Leuven · BECliniques Universitaires Saint-Luc · BEMaastricht University Medical Centre · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A fat-rich energy-dense diet is an important cause of insulin resistance. Stimulation of fat turnover in muscle cells during dietary fat challenge may contribute to maintenance of insulin sensitivity. Exercise in the fasted state markedly stimulates energy provision via fat oxidation. Therefore, we investigated whether exercise training in the fasted state is more potent than exercise in the fed state to rescue whole-body glucose tolerance and insulin sensitivity during a period of hyper-caloric fat-rich diet. Healthy male volunteers (18-25 y) received a hyper-caloric (∼+30% kcal day(-1)) fat-rich (50% of kcal) diet for 6 weeks. Some of the subjects performed endurance exercise training (4 days per week) in the fasted state (F; n = 10), whilst the others ingested carbohydrates before and during the training sessions (CHO; n = 10). The control group did not train (CON; n = 7). Body weight increased in CON (+3.0 ± 0.8 kg) and CHO (+1.4 ± 0.4 kg) (P < 0.01), but not in F (+0.7 ± 0.4 kg, P = 0.13). Compared with CON, F but not CHO enhanced whole-body glucose tolerance and the Matsuda insulin sensitivity index (P < 0.05). Muscle GLUT4 protein content was increased in F (+28%) compared with both CHO (P = 0.05) and CON (P < 0.05). Furthermore, only training in F elevated AMP-activated protein kinase α phosphorylation (+25%) as well as up-regulated fatty acid translocase/CD36 and carnitine palmitoyltransferase 1 mRNA levels compared with CON (∼+30%). High-fat diet increased intramyocellular lipid but not diacylglycerol and ceramide contents, either in the absence or presence of training. This study for the first time shows that fasted training is more potent than fed training to facilitate adaptations in muscle and to improve whole-body glucose tolerance and insulin sensitivity during hyper-caloric fat-rich diet.

Indexed as

Body CompositionDietary FatsExerciseFastingFatty Acids, NonesterifiedGlucoseGlycogenHumansInsulin ResistanceLipid MetabolismMaleMuscle, SkeletalPhysical EnduranceYoung AdultDietary FatsFatty Acids, NonesterifiedGlucoseGlycogen

Identifiers

PMID20837645
PMCPMC3002457
OpenAlexW1610355527

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.