Evidence map›Paper›PMID 20847403›Full record

Trial reportJournal of Alzheimer's disease : JAD2010

Aerobic exercise improves cognition for older adults with glucose intolerance, a risk factor for Alzheimer's disease.

Laura D Baker, Laura L Frank, Karen Foster-Schubert, Pattie S Green, Charles W Wilkinson, Anne McTiernan, Brenna A Cholerton, Stephen R Plymate, Mark A Fishel, G Stennis Watson and 3 more

4 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of Alzheimer's disease : JAD, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 135 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed, 6 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02653638 early_phase1completednot on this mapstarted 2016, after this paper: background citation

Cerebral Vasodilator Responses in Sedentary and Exercise Trained Humans

TypeinterventionalSponsorUniversity of Wisconsin, MadisonRan2016 to 2019Enrolled80ConditionsCerebrovascular CirculationArmsControl, Indomethacin
NCT02663934 naterminatednot on this mapstarted 2016, after this paper: background citation

Exercise Training to Improve Brain Health in Older HIV+ Individuals

TypeinterventionalSponsorWashington University School of MedicineRan2016 to 2020Enrolled75ConditionsHIVArmsExercise, Stretching and Social Interaction
NCT02729428 completednot on this mapstarted 2016, after this paper: background citation

MRI Biomarkers of Risk in Sedentary and Exercise Trained Humans

TypeobservationalSponsorUniversity of Wisconsin, MadisonRan2016 to 2019Enrolled71ConditionsCerebrovascular CirculationArmsMRI
NCT04962061 nacompletednot on this mapstarted 2021, after this paper: background citation

Impacts of Aerobic, Resistance and Cognitive Training Interventions on Neurocognitive Functions in Older Adults With Cardiovascular Risk Factors.

TypeinterventionalSponsorLouis BhererRan2021 to 2026Enrolled159ConditionsAging, Cardiovascular Risk FactorArmsCognitive Training, Aerobic and resistance exercises, Stretching and Toning
3 · Its place in the literature

Who cites it

135 citing papers in PubMed, 6 syntheses or guidelines pooled it, 292 citations in OpenAlex.

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  8. Baseline cognition and demographic, lifestyle, and cardiovascular risk factors in US POINTER.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Laura D BakerDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA. ldbaker@uw.edu
Laura L Frank
Karen Foster-Schubert
Pattie S Green
Charles W Wilkinson
Anne McTiernan
Brenna A Cholerton
Stephen R Plymate
Mark A Fishel
G Stennis Watson
Glen E Duncan
Pankaj D Mehta
Suzanne Craft
University of Washington · USFred Hutch Cancer Center · USGeriatric Research Education and Clinical Center · USNew York State Office for People With Developmental Disabilities · USUniversity of Puget Sound · US

Funding

Institute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4M
Institute for Translational Health Science (KL2)KL2RR025015 · NCRR · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2007 to 2011
$9.3M
NCATS NIH HHS UL1 TR000423NCRR NIH HHS KL2 RR025015
6 · The paper itself

Abstract

Impaired glucose regulation is a defining characteristic of type 2 diabetes mellitus (T2DM) pathology and has been linked to increased risk of cognitive impairment and dementia. Although the benefits of aerobic exercise for physical health are well-documented, exercise effects on cognition have not been examined for older adults with poor glucose regulation associated with prediabetes and early T2DM. Using a randomized controlled design, twenty-eight adults (57-83 y old) meeting 2-h tolerance test criteria for glucose intolerance completed 6 months of aerobic exercise or stretching, which served as the control. The primary cognitive outcomes included measures of executive function (Trails B, Task Switching, Stroop, Self-ordered Pointing Test, and Verbal Fluency). Other outcomes included memory performance (Story Recall, List Learning), measures of cardiorespiratory fitness obtained via maximal-graded exercise treadmill test, glucose disposal during hyperinsulinemic-euglycemic clamp, body fat, and fasting plasma levels of insulin, cortisol, brain-derived neurotrophic factor, insulin-like growth factor-1, amyloid-β (Aβ40 and Aβ42). Six months of aerobic exercise improved executive function (MANCOVA, p=0.04), cardiorespiratory fitness (MANOVA, p=0.03), and insulin sensitivity (p=0.05). Across all subjects, 6-month changes in cardiorespiratory fitness and insulin sensitivity were positively correlated (p=0.01). For Aβ42, plasma levels tended to decrease for the aerobic group relative to controls (p=0.07). The results of our study using rigorous controlled methodology suggest a cognition-enhancing effect of aerobic exercise for older glucose intolerant adults. Although replication in a larger sample is needed, our findings potentially have important therapeutic implications for a growing number of adults at increased risk of cognitive decline.

Indexed as

ExerciseAgedAlzheimer DiseaseAmyloid beta-PeptidesBrain-Derived Neurotrophic FactorCognition DisordersExecutive FunctionExercise TherapyFemaleFollow-Up StudiesGlucose Clamp TechniqueGlucose IntoleranceHeart RateHumansInsulin-Like Growth Factor IMaleAmyloid beta-PeptidesBrain-Derived Neurotrophic FactorInsulin-Like Growth Factor I

Identifiers

PMID20847403
PMCPMC3049111
OpenAlexW1571333537

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.