ArticleImmunogenetics2010
Origin and diversification of the L-amino oxidase family in innate immune defenses of animals.
Article in Immunogenetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Ancient fish lineages illuminate toll-like receptor diversification in early vertebrate evolution.Immunogenetics · 2023Article
- Interleukin 4 inducible 1 gene (IL4I1) is induced in chicken phagocytes by Salmonella Enteritidis infection.Veterinary research · 2020Article
- L-amino acid oxidase from Bothrops atrox snake venom triggers autophagy, apoptosis and necrosis in normal human keratinocytes.Scientific reports · 2019Article
- Hippocampal metabolism of amino acids by L-amino acid oxidase is involved in fear learning and memory.Scientific reports · 2018Article
- Amplification and bioinformatics analysis of conserved FAD-binding region of L-amino acid oxidase (Computational and structural biotechnology journal · 2018Article
- Transcriptomic and Quantitative Proteomic Analyses Provide Insights Into the Phagocytic Killing of Hemocytes in the OysterFrontiers in immunology · 2018Article
- Membrane binding of the insertion sequence of Proteus vulgaris L-amino acid deaminase stabilizes protein structure and increases catalytic activity.Scientific reports · 2017Article
- Tracing the dynamics of gene transcripts after organismal death.Open biology · 2017Article
- Distribution in Different Organisms of Amino Acid Oxidases with FAD or a Quinone As Cofactor and Their Role as Antimicrobial Proteins in Marine Bacteria.Marine drugs · 2015Review
- Cloning and characterization of the gene for L-amino acid oxidase in hybrid tilapia.Molecular biology reports · 2015Article
- Fungal platform for direct chiral phosphonic building blocks production. Closer look on conversion pathway.Applied biochemistry and biotechnology · 2015Article
- The identification of loci for immune traits in chickens using a genome-wide association study.PloS one · 2015Article
- Article
- EvoluCode: Evolutionary Barcodes as a Unifying Framework for Multilevel Evolutionary Data.Evolutionary bioinformatics online · 2012Article
- Evaluation of an antimicrobial L-amino acid oxidase and peptide derivatives from Bothropoides mattogrosensis pitviper venom.PloS one · 2012Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
L-amino acid oxidases (LAOs), because they produce hydrogen peroxide as a by-product, function in innate immune defenses of both vertebrates and mollusks. Phylogenetic analysis revealed two major subfamilies of LAOs: (1) a subfamily including LAOs from vertebrates and mainly from Terrabacteria and (2) a subfamily including LAOs from mollusks and Hydrobacteria. These subfamilies thus originated early in the history of life, implying that their innate immune functions in vertebrates and mollusks have evolved separately. Mammalian LAOs were found to belong to three separate clades: (1) LAO1, (2) LAO2, and (3) IL4I1. Phylogenetic analysis supported the hypothesis that LAO1 and LAO2 arose by a gene duplication prior to the divergence of marsupials from placental mammals, while IL4I1 duplicated from the ancestor of the LAO1 and LAO2 prior to the divergence of tetrapods from bony fishes. Mammalian IL4I1 clustered with LAOs from bony fishes, and these molecules shared a number of unique sequence features, including both amino acid replacements and a unique two-codon deletion. It is certain such unique features may be functionally important, especially three unique amino acid replacements in close proximity to the putative active site.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.