ArticleFood & nutrition research2010
Assessment of health claims, content, and safety of herbal supplements containing Ginkgo biloba.
Article in Food & nutrition research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Evaluation of a multi-herb supplement for erectile dysfunction: a randomized double-blind, placebo-controlled study.BMC complementary and alternative medicine · 2012Trial
- Review
- Isovitexin Inhibits Ginkgolic Acids-Induced Inflammation Through Downregulating SHP2 Activation.Frontiers in pharmacology · 2021Article
- Comparison of phytochemical composition of Ginkgo biloba extracts using a combination of non-targeted and targeted analytical approaches.Analytical and bioanalytical chemistry · 2020Article
- Systemic exposure to Ginkgo biloba extract in male F344/NCrl rats: Relevance to humans.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2019Article
- Effects of β-glucosidase and α-rhamnosidase on the Contents of Flavonoids, Ginkgolides, and Aroma Components in Ginkgo Tea Drink.Molecules (Basel, Switzerland) · 2019Article
- How similar is similar enough? A sufficient similarity case study with Ginkgo biloba extract.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2018Article
- Review of Ginkgo biloba-induced toxicity, from experimental studies to human case reports.Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews · 2017Review
- The Ginkgo biloba Extract Reverses the Renal Effects of Titanium Dioxide Nanoparticles in Adult Male Rats.Biochemistry research international · 2016Article
- Commonly Used Dietary Supplements on Coagulation Function during Surgery.Medicines (Basel, Switzerland) · 2015Article
- Toxicity and carcinogenicity studies of Ginkgo biloba extract in rat and mouse: liver, thyroid, and nose are targets.Toxicologic pathology · 2014Article
- Mechanistic evaluation of Ginkgo biloba leaf extract-induced genotoxicity in L5178Y cells.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Mixtures research at NIEHS: an evolving program.Toxicology · 2013Article
- Hepatocellular carcinomas in B6C3F1 mice treated with Ginkgo biloba extract for two years differ from spontaneous liver tumors in cancer gene mutations and genomic pathways.Toxicologic pathology · 2013Article
- Effects of Ginkgo biloba on chemically-induced mammary tumors in rats receiving tamoxifen.BMC complementary and alternative medicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEuropean Regulation 1924/2006 states that all health claims made on foods need to be substantiated scientifically.
objectiveTo apply the PASSCLAIM criteria for the scientific substantiation of health claims on foods to herbal supplements containing Ginkgo biloba. Evaluation of three selected claimed health effects for G. biloba (improvement of blood circulation, improvement of symptoms of old age, and improvement of memory) was achieved through review of publicly available scientific data. A total of 35 human intervention studies were evaluated. Commercially available products claimed to contain mainly G. biloba (N=29) were randomly sampled in the Netherlands and analyzed for their content on ginkgo extract. Also, a toxicological risk assessment was performed.
resultsThe three selected health claims investigated could not be substantiated. This was mainly because of a lack of data from studies in healthy volunteers. In most studies results performed with a 24% standardized G. biloba extract were described. However, our chemical analysis showed that 25 of the 29 sampled products did not contain the required minimum 24% standardized extract. Moreover, in most preparations the content of substances typical for G. biloba did not conform to what was declared on the label. Since toxicity data for G. biloba are very limited, a safety limit could not be established.
conclusionsEvidence is lacking for three health claims of herbal products with G. biloba. Neither safety nor efficacy can be guaranteed at the recommended daily dose. The multidisciplinary approach described in this paper provides good insight into issues that are relevant for the evaluation of health claims for herbal food supplements.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.