Trial reportTrials2010
Study protocol: the Adherence and Intensification of Medications (AIM) study--a cluster randomized controlled effectiveness study.
Trial report in Trials, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00495794 (Adherence and Intensification of Medications), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adherence and Intensification of Medications: A Population-Based Clinical Pharmacists Implementation Study Among Hypertensive Diabetes Patients
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Developing a framework for a novel multi-disciplinary, multi-agency intervention(s), to improve medication management in community-dwelling older people on complex medication regimens (MEMORABLE)--a realist synthesis.Systematic reviews · 2017Pooled it
- The Shared Health Appointments and Reciprocal Enhanced Support (SHARES) study: study protocol for a randomized trial.Trials · 2017Trial
- Trial
- Hypertension Management in Primary Care.Deutsches Arzteblatt international · 2016Trial
- Can phone-based motivational interviewing improve medication adherence to antiplatelet medications after a coronary stent among racial minorities? A randomized trial.Journal of general internal medicine · 2015Trial
- Hypertension management in primary care: study protocol for a cluster randomized controlled trial.Trials · 2015Trial
- Trial
- Randomized trial of telephone outreach to improve medication adherence and metabolic control in adults with diabetes.Diabetes care · 2014Trial
- Trial
- Operationalizing rapid implementation science for responsive HIV programs.Frontiers in health services · 2026Article
- Evaluating Documentation of Prescribing Training Experiences in Pharmacy Residency Programs.Medical science educator · 2021Article
- Study protocol: Using peer support to aid in prevention and treatment in prediabetes (UPSTART).Contemporary clinical trials · 2020Article
- Testing a behavioral intervention to improve adherence to adjuvant endocrine therapy (AET).Contemporary clinical trials · 2019Article
- Primary care provider adherence to an alert for intensification of diabetes blood pressure medications before and after the addition of a "chart closure" hard stop.Journal of the American Medical Informatics Association : JAMIA · 2018Article
- Development and application of the RE-AIM QuEST mixed methods framework for program evaluation.Preventive medicine reports · 2017Article
- Reach and Validity of an Objective Medication Adherence Measure Among Safety Net Health Plan Members with Diabetes: A Cross-Sectional Study.Journal of managed care & specialty pharmacy · 2015Article
- Factors associated with persistent poorly controlled diabetes mellitus: clues to improving management in patients with resistant poor control.Chronic illness · 2014Article
- Behavioral interventions to improve hypertension control in the Veterans Affairs healthcare system.Journal of clinical hypertension (Greenwich, Conn.) · 2014Review
- Characteristics of diabetic patients associated with achieving and maintaining blood pressure targets in the Adherence and Intensification of Medications program.Chronic illness · 2014Article
- Most important outcomes research papers on hypertension.Circulation. Cardiovascular quality and outcomes · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundMany patients with diabetes have poor blood pressure (BP) control. Pharmacological therapy is the cornerstone of effective BP treatment, yet there are high rates both of poor medication adherence and failure to intensify medications. Successful medication management requires an effective partnership between providers who initiate and increase doses of effective medications and patients who adhere to the regimen.
methodsIn this cluster-randomized controlled effectiveness study, primary care teams within sites were randomized to a program led by a clinical pharmacist trained in motivational interviewing-based behavioral counseling approaches and authorized to make BP medication changes or to usual care. This study involved the collection of data during a 14-month intervention period in three Department of Veterans Affairs facilities and two Kaiser Permanente Northern California facilities. The clinical pharmacist was supported by clinical information systems that enabled proactive identification of, and outreach to, eligible patients identified on the basis of poor BP control and either medication refill gaps or lack of recent medication intensification. The primary outcome is the relative change in systolic blood pressure (SBP) measurements over time. Secondary outcomes are changes in Hemoglobin A1c, low-density lipoprotein cholesterol (LDL), medication adherence determined from pharmacy refill data, and medication intensification rates. DISCUSSION: Integration of the three intervention elements--proactive identification, adherence counseling and medication intensification--is essential to achieve optimal levels of control for high-risk patients. Testing the effectiveness of this intervention at the team level allows us to study the program as it would typically be implemented within a clinic setting, including how it integrates with other elements of care.
trial registrationThe ClinicalTrials.gov registration number is NCT00495794.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.