Evidence map›Paper›PMID 21030499›Full record

Trial reportDiabetes2011

Coffee and caffeine consumption in relation to sex hormone-binding globulin and risk of type 2 diabetes in postmenopausal women.

Atsushi Goto, Yiqing Song, Brian H Chen, JoAnn E Manson, Julie E Buring, Simin Liu

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Atsushi GotoDepartment of Epidemiology, Center for Metabolic Disease Prevention, University of California, Los Angeles, USA.
Yiqing Song
Brian H Chen
JoAnn E Manson
Julie E Buring
Simin Liu

Funding

Women's Health Study: Continued Follow-upR01CA047988 · BRIGHAM AND WOMEN'S HOSPITAL · 1991 to 2005
$15.2M
TRIAL OF VITAMIN E, BETA-CAROTENE &ASPRIN IN WOMENR01HL043851 · BRIGHAM AND WOMEN'S HOSPITAL · 1991 to 2000
$1.6M
Training Grant in Genomic Analysis and InterpretationT32HG002536 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2002 to 2025
$1.3M
Steroid Hormones, Adipose-cytokines, and Diabetes RiskR01DK066401 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2004 to 2005
$1.1M
Women's Health Study: Continued Follow-UpR01HL080467 · BRIGHAM AND WOMEN'S HOSPITAL · 2005 to 2005
$889k
NCI NIH HHS CA 047988NCI NIH HHS R01 CA047988NHGRI NIH HHS T32 HG002536NHGRI NIH HHS T32-HG002536NHLBI NIH HHS HL 043851NHLBI NIH HHS HL 080467NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL080467NIDDK NIH HHS DK066401NIDDK NIH HHS K01 DK078846NIDDK NIH HHS K01-DK078846NIDDK NIH HHS R01 DK066401
6 · The paper itself

Abstract

objectiveCoffee consumption has been inversely associated with type 2 diabetes risk, but its mechanisms are largely unknown. We aimed to examine whether plasma levels of sex hormones and sex hormone-binding globulin (SHBG) may account for the inverse association between coffee consumption and type 2 diabetes risk. RESEARCH DESIGN AND

methodsWe conducted a case-control study nested in the prospective Women's Health Study (WHS). During a median follow-up of 10 years, 359 postmenopausal women with newly diagnosed type 2 diabetes were matched with 359 control subjects by age, race, duration of follow-up, and time of blood draw.

resultsCaffeinated coffee was positively associated with SHBG but not with sex hormones. Multivariable-adjusted geometric mean levels of SHBG were 26.6 nmol/l among women consuming ≥4 cups/day of caffeinated coffee and 23.0 nmol/l among nondrinkers (P for trend = 0.01). In contrast, neither decaffeinated coffee nor tea was associated with SHBG or sex hormones. The multivariable-adjusted odds ratio (OR) of type 2 diabetes for women consuming ≥4 cups/day of caffeinated coffee compared with nondrinkers was 0.47 (95% CI 0.23-0.94; P for trend = 0.047). The association was largely attenuated after further adjusting for SHBG (OR 0.71 [95% CI 0.31-1.61]; P for trend = 0.47). In addition, carriers of rs6259 minor allele and noncarriers of rs6257 minor allele of SHBG gene consuming ≥2 cups/day of caffeinated coffee had lower risk of type 2 diabetes in directions corresponding to their associated SHBG.

conclusionsOur findings suggest that SHBG may account for the inverse association between coffee consumption and type 2 diabetes risk among postmenopausal women.

Indexed as

PostmenopauseAgedBeveragesCaffeineCoffeeDiabetes Mellitus, Type 2DietDouble-Blind MethodFeeding BehaviorFemaleGonadal Steroid HormonesHumansMiddle AgedMultivariate AnalysisOdds RatioSex Hormone-Binding GlobulinCaffeineCoffeeGonadal Steroid HormonesSex Hormone-Binding Globulin

Identifiers

PMID21030499
PMCPMC3012180

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.