ArticleNeuron2010
Visual activity regulates neural progenitor cells in developing xenopus CNS through musashi1.
Article in Neuron, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- BRCA1 and ELK-1 regulate neural progenitor cell fate in the optic tectum in response to visual experience inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- β-Catenin and SOX2 Interaction Regulate Visual Experience-Dependent Cell Homeostasis in the DevelopingInternational journal of molecular sciences · 2023Article
- Electrical charge on ferroelectric nanocomposite membranes enhances SHED neural differentiation.Bioactive materials · 2023Article
- Epigenetic regulation of GABAergic differentiation in the developing brain.Frontiers in cellular neuroscience · 2022Article
- Glia Regulate the Development, Function, and Plasticity of the Visual System From Retina to Cortex.Frontiers in neural circuits · 2022Review
- A Simple and Efficient Method for Visualizing Individual CellsFrontiers in neural circuits · 2020Article
- Nutrient restriction causes reversible G2 arrest inDevelopment (Cambridge, England) · 2019Article
- Enhanced visual experience rehabilitates the injured brain in Xenopus tadpoles in an NMDAR-dependent manner.Journal of neurophysiology · 2019Article
- Visual Experience Facilitates BDNF-Dependent Adaptive Recruitment of New Neurons in the Postembryonic Optic Tectum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Reversible developmental stasis in response to nutrient availability in the Xenopus laevis central nervous system.The Journal of experimental biology · 2017Article
- Article
- Mapping neurogenesis onset in the optic tectum of Xenopus laevis.Developmental neurobiology · 2016Article
- Thyroid Hormone Acts Locally to Increase Neurogenesis, Neuronal Differentiation, and Dendritic Arbor Elaboration in the Tadpole Visual System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Neural Activity-Dependent Regulation of Radial Glial Filopodial Motility Is Mediated by Glial cGMP-Dependent Protein Kinase 1 and Contributes to Synapse Maturation in the Developing Visual System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- HDAC3 But not HDAC2 Mediates Visual Experience-Dependent Radial Glia Proliferation in the DevelopingFrontiers in cellular neuroscience · 2016Article
- An in vivo screen to identify candidate neurogenic genes in the developing Xenopus visual system.Developmental biology · 2015Article
- Article
- Valproate-induced neurodevelopmental deficits in Xenopus laevis tadpoles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- HDAC1 regulates the proliferation of radial glial cells in the developing Xenopus tectum.PloS one · 2015Article
- Region-specific regulation of voltage-gated intrinsic currents in the developing optic tectum of the Xenopus tadpole.Journal of neurophysiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Regulation of progenitor cell fate determines the numbers of neurons in the developing brain. While proliferation of neural progenitors predominates during early central nervous system (CNS) development, progenitor cell fate shifts toward differentiation as CNS circuits develop, suggesting that signals from developing circuits may regulate proliferation and differentiation. We tested whether activity regulates neurogenesis in vivo in the developing visual system of Xenopus tadpoles. Both cell proliferation and the number of musashi1-immunoreactive progenitors in the optic tectum decrease as visual system connections become stronger. Visual deprivation for 2 days increased proliferation of musashi1-immunoreactive radial glial progenitors, while visual experience increased neuronal differentiation. Morpholino-mediated knockdown and overexpression of musashi1 indicate that musashi1 is necessary and sufficient for neural progenitor proliferation in the CNS. These data demonstrate a mechanism by which increased brain activity in developing circuits decreases cell proliferation and increases neuronal differentiation through the downregulation of musashi1 in response to circuit activity.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.