SynthesisThe Cochrane database of systematic reviews2010
Probiotics for treating persistent diarrhoea in children.
Synthesis in The Cochrane database of systematic reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 42 citations in OpenAlex.
- Gut microbiota patterns associated with duration of diarrhea in children under five years of age in Ethiopia.Nature communications · 2024Article
- Do Your Kids Get What You Paid for? Evaluation of Commercially Available Probiotic Products Intended for Children in the Republic of the Philippines and the Republic of Korea.Foods (Basel, Switzerland) · 2020Article
- Emerging Priorities for Microbiome Research.Frontiers in microbiology · 2020Review
- Effect of microencapsulation onIranian journal of microbiology · 2019Article
- Probiotics and gastrointestinal conditions: An overview of evidence from the Cochrane Collaboration.Nutrition (Burbank, Los Angeles County, Calif.) · 2018Review
- Altered transcription of murine genes induced in the small bowel by administration of probiotic strain Lactobacillus rhamnosus HN001.Applied and environmental microbiology · 2014Article
- Anti-infective activities of lactobacillus strains in the human intestinal microbiota: from probiotics to gastrointestinal anti-infectious biotherapeutic agents.Clinical microbiology reviews · 2014Review
- Review
- Community health care: therapeutic opportunities in the human microbiome.Science translational medicine · 2011Article
- Evidence Aid and the disaster response in Pakistan and Haiti.The Cochrane database of systematic reviews · 2010Article
Corrections and comments
- Commented on by
- Commented on byCochrane column.2012
- Updated by
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPersistent diarrhoea (diarrhoea lasting more than 14 days) accounts for one third of all diarrhoea related deaths in developing countries in some studies. Probiotics may help treatment.
objectivesTo evaluate probiotics for treating persistent diarrhoea in children. SEARCH STRATEGY: In August 2010, we searched the Cochrane Infectious Diseases Group Specialized Register, CENTRAL, MEDLINE, EMBASE, and LILACS. We also contacted authors of included trials and organizations working in the field, and checked reference lists. SELECTION CRITERIA: Randomized controlled trials comparing a specified probiotic agent with placebo or no probiotic in children with persistent diarrhoea. DATA COLLECTION AND ANALYSIS: Two review authors assessed the eligibility, risk of bias, extracted and analysed data. Differences were resolved by discussion. Statistical analysis were performed using the fixed-effect model and the results were expressed as mean difference (MD) for continuous outcomes with 95% confidence intervals (CI). MAIN
resultsFour trials were included, with a total number of 464 participants; one trial had a low risk of bias. Meta-analysis showed that probiotics reduced the duration of persistent diarrhoea (mean difference 4.02 days, 95% CI 4.61 to 3.43 days, n=324, 2 trials). Stool frequency was reduced with probiotics in two trials. One trial reported a shorter hospital stay, which was significant, but numbers were small. No adverse events were reported. AUTHORS'
conclusionsThere is limited evidence suggesting probiotics may be effective in treating persistent diarrhoea in children.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.