ArticleBiophysical journal2010
A biophysical model of electrical activity in human β-cells.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 61 citations in OpenAlex.
- On the role of L-type Ca2+ and BK channels in a biophysical model of cartwheel interneurons.PLoS computational biology · 2026Article
- Deconstructing the integrated oscillator model for pancreatic β-cells.Mathematical biosciences · 2023Article
- Multilevel synchronization of humanFrontiers in network physiology · 2023Article
- The effects of beta-cell mass and function, intercellular coupling, and islet synchrony on [Formula: see text] dynamics.Scientific reports · 2021Article
- Article
- From Local to Global Modeling for Characterizing Calcium Dynamics and Their Effects on Electrical Activity and Exocytosis in Excitable Cells.International journal of molecular sciences · 2019Article
- Beta-cell hubs maintain CaIslets · 2018Article
- Review
- Concise Whole-Cell Modeling of BKBiophysical journal · 2017Article
- Requirements for multi-level systems pharmacology models to reach end-usage: the case of type 2 diabetes.Interface focus · 2016Review
- Mathematical Modeling of Interacting Glucose-Sensing Mechanisms and Electrical Activity Underlying Glucagon-Like Peptide 1 Secretion.PLoS computational biology · 2015Article
- Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes.Molecular aspects of medicine · 2015Review
- Reactive oxygen and nitrogen species disturb Ca(2+) oscillations in insulin-secreting MIN6 β-cells.Islets · 2015Article
- Mathematical modeling of heterogeneous electrophysiological responses in human β-cells.PLoS computational biology · 2014Article
- Mathematical models of electrical activity of the pancreatic β-cell: a physiological review.Islets · 2014Review
- Article
- Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion.The Journal of biological chemistry · 2013Article
- Multiscale modelling of insulin secretion during an intravenous glucose tolerance test.Interface focus · 2013Article
- The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function.Diabetologia · 2012Article
- Block of Kv1.7 potassium currents increases glucose-stimulated insulin secretion.EMBO molecular medicine · 2012Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrical activity in pancreatic β-cells plays a pivotal role in glucose-stimulated insulin secretion by coupling metabolism to calcium-triggered exocytosis. Mathematical models based on rodent data have helped in understanding the mechanisms underlying the electrophysiological patterns observed in laboratory animals. However, human β-cells differ in several aspects, and in particular in their electrophysiological characteristics, from rodent β-cells. Hence, from a clinical perspective and to obtain insight into the defects in insulin secretion relevant for diabetes mellitus, it is important to study human β-cells. This work presents the first mathematical model of electrical activity based entirely on published ion channel characteristics of human β-cells. The model reproduces satisfactorily a series of experimentally observed patterns in human β-cells, such as spiking and rapid bursting electrical activity, and their response to a range of ion channel antagonists. The possibility of Human Ether-a-Go-Go-related- and leak channels as drug targets for diabetes treatment is discussed based on model results.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.