ArticleRespiratory physiology & neurobiology2011
Chronic hyperoxia alters the expression of neurotrophic factors in the carotid body of neonatal rats.
Article in Respiratory physiology & neurobiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Effect of Intermittent Hypoxemia and Hyperoxemia during the Neonatal Period on Control of Breathing Function among Infants Born Extremely Preterm.The Journal of pediatrics · 2025Observational
- Neurochemical Plasticity of the Carotid Body.Advances in anatomy, embryology, and cell biology · 2023Article
- Comparative morphological and molecular studies on the oxygen-chemoreceptive cells in the carotid body and fish gills.Cell and tissue research · 2021Review
- Experimental Evidence of AFrontiers in physiology · 2021Article
- Growth Factors in the Carotid Body-An Update.International journal of molecular sciences · 2020Review
- Mechanistic actions of oxygen and methylxanthines on respiratory neural control and for the treatment of neonatal apnea.Respiratory physiology & neurobiology · 2020Review
- Combined effects of intermittent hyperoxia and intermittent hypercapnic hypoxia on respiratory control in neonatal rats.Respiratory physiology & neurobiology · 2019Article
- Central and peripheral chemoreceptors in sudden infant death syndrome.The Journal of physiology · 2018Review
- Comparative Response of Brain to Chronic Hypoxia and Hyperoxia.International journal of molecular sciences · 2017Review
- Role of TrkB during the postnatal development of the rat carotid body.Respiratory physiology & neurobiology · 2015Article
- Perinatal hyperoxic exposure reconfigures the central respiratory network contributing to intolerance to anoxia in newborn rat pups.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Carotid chemoreceptor development in mice.Respiratory physiology & neurobiology · 2013Review
- Peripheral-central chemoreceptor interaction and the significance of a critical period in the development of respiratory control.Respiratory physiology & neurobiology · 2013Review
- Chronic hyperoxia and the development of the carotid body.Respiratory physiology & neurobiology · 2013Review
- Effect of hyperoxic exposure during early development on neurotrophin expression in the carotid body and nucleus tractus solitarii.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Carotid body growth during chronic postnatal hyperoxia.Respiratory physiology & neurobiology · 2012Article
- Recovery of carotid body O2 sensitivity following chronic postnatal hyperoxia in rats.Respiratory physiology & neurobiology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Chronic exposure to hyperoxia alters the postnatal development and innervation of the rat carotid body. We hypothesized that this plasticity is related to changes in the expression of neurotrophic factors or related proteins. Rats were reared in 60% O(2) from 24 to 36h prior to birth until studied at 3d of age (P3). Protein levels for brain-derived neurotrophic factor (BDNF) were significantly reduced (-70%) in the P3 carotid body, while protein levels for its receptor, tyrosine kinase B, and for glial cell line-derived neurotrophic factor (GDNF) were unchanged. Transcript levels in the carotid body were downregulated for the GDNF receptor Ret (-34%) and the neuropeptide Vgf (-67%), upregulated for Cbln1 (+205%), and unchanged for Fgf2; protein levels were not quantified for these genes. Immunohistochemical analysis revealed that Vgf and Cbln1 proteins are expressed within the carotid body glomus cells. These data suggest that BDNF, and perhaps other neurotrophic factors, contribute to abnormal carotid body function following perinatal hyperoxia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.