Evidence map›Paper›PMID 21094444›Full record

ReviewMagnetic resonance imaging clinics of North America2010

Quantification of liver fat with magnetic resonance imaging.

Scott B Reeder, Claude B Sirlin

2 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in Magnetic resonance imaging clinics of North America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 182 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
182citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05042505 nacompletedstarted 2022, after this paper: background citation

Effect of Dapagliflozin vs Sitagliptin on Liver Fat Accumulation and Body Composition in Patients With Diabetes Mellitus and Liver Transplantation: a Randomized Controlled Trial

Ran2022Enrolled100Registered outcomes5Posted comparisons0ConditionsDiabetes Mellitus, Liver Transplant; ComplicationsArmsDapagliflozin 10mg Tab, Sitagliptin 100mg
Open the trial in the graph
NCT02686476 nacompletednot on this mapstarted 2016, after this paper: background citation

Effect of Empagliflozin on Liver Fat Content in Patients With Type 2 Diabetes: A 12-week Randomized Clinical Study

TypeinterventionalSponsorMedanta, The Medicity, IndiaRan2016 to 2017Enrolled100ConditionsNon Alcoholic Fatty Liver DiseaseArmsEmpagliflozin
3 · Its place in the literature

Who cites it

182 citing papers in PubMed, 1 synthesis or guideline pooled it, 327 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  6. T1 bias in chemical shift-encoded liver fat-fraction: role of the flip angle.Journal of magnetic resonance imaging : JMRI · 2014
    Trial
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  10. Review
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  20. Obesity and hepatic steatosis in STAT3 hyper-IgE syndrome.The journal of allergy and clinical immunology. In practice · 2026
    Article

122 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Scott B ReederLiver Imaging Research Program, Department of Radiology, University of Wisconsin, E1/374 CSC, 600 Highland Avenue, Madison, WI 53792-3252, USA. sreeder@wisc.edu
Claude B Sirlin
University of California, San Diego · USUniversity of Wisconsin–Madison · US

Funding

Technical Validation of MRI Biomarkers of Liver FatR01DK088925 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B., SIRLIN, CLAUDE B · 2010 to 2021
$7.1M
Technical Development of Quantitative Biomarkers of Fatty Liver Disease with MRIR01DK083380 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B. · 2010 to 2013
$1.2M
NIDDK NIH HHS R01 DK083380NIDDK NIH HHS R01 DK088925
6 · The paper itself

Abstract

Intracellular fat accumulation is common feature of liver disease. Intracellular fat (steatosis) is the histologic hallmark of nonalcoholic fatty liver disease but also may occur with alcohol abuse, viral hepatitis, HIV and genetic lipodystrophies, and chemotherapy. This article reviews emerging MR imaging techniques that attempt to quantify liver fat. The content provides an overview of fatty liver disease and diseases where fat is an important disease feature. Also discussed is the current use and limitation of nontargeted biopsy in diffuse liver disease and why quantitative noninvasive biomarkers of liver fat would be beneficial.

Indexed as

AlgorithmsAdipose TissueFatty LiverHumansImage EnhancementImage Interpretation, Computer-AssistedLiverMagnetic Resonance ImagingPattern Recognition, AutomatedReproducibility of ResultsSensitivity and Specificity

Identifiers

PMID21094444
PMCPMC3002753
OpenAlexW2103139789

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.