ArticleVascular health and risk management2010
Prognostic value of changes in arterial stiffness in men with coronary artery disease.
Article in Vascular health and risk management, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03309618 (Improving Arterial Wall Characteristics in Patients After Myocardial Infarction With a Very Low Dose of Fluvastatin and Valsartan), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving Arterial Wall Characteristics in Patients After Myocardial Infarction With a Very Low Dose of Fluvastatin and Valsartan: Proof-of-concept Study
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- I Luso-Brazilian Positioning on Central Arterial Pressure.Arquivos brasileiros de cardiologia · 2017Guideline
- Recommendations for Improving and Standardizing Vascular Research on Arterial Stiffness: A Scientific Statement From the American Heart Association.Hypertension (Dallas, Tex. : 1979) · 2015Guideline
- HIV-Related Arterial Stiffness in Malawian Adults Is Associated With the Proportion of PD-1-Expressing CD8+ T Cells and Reverses With Antiretroviral Therapy.The Journal of infectious diseases · 2019Trial
- Improving Arterial Wall Characteristics in Patients After Myocardial Infarction with a Very Low Dose of Fluvastatin and Valsartan: A Proof-of-Concept Study.Medical science monitor : international medical journal of experimental and clinical research · 2018Trial
- Relationship between bleeding risk and arterial stiffness in patients with cerebral aneurysms.Turkish journal of medical sciences · 2025Article
- Brazilian Guidelines of Hypertension - 2020.Arquivos brasileiros de cardiologia · 2021Article
- Comparison of the Brachial-ankle Pulse Wave Velocity between Patients with Acute Coronary Syndrome and Effort Angina Pectoris.Internal medicine (Tokyo, Japan) · 2018Article
- History of Asthma From Childhood and Arterial Stiffness in Asymptomatic Young Adults: The Bogalusa Heart Study.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Brachial-ankle pulse wave velocity, cardio-ankle vascular index, and prognosis.Vascular health and risk management · 2018Review
- Nutrition and other lifestyle influences on arterial aging.Ageing research reviews · 2017Review
- Brachial-Ankle Pulse Wave Velocity: Background, Method, and Clinical Evidence.Pulse (Basel, Switzerland) · 2016Review
- Association of arterial stiffness with coronary flow reserve in revascularized coronary artery disease patients.World journal of cardiology · 2016Article
- Impact of Framingham risk score, flow-mediated dilation, pulse wave velocity, and biomarkers for cardiovascular events in stable angina.Journal of Korean medical science · 2014Article
- Arterial distensibility in patients with ruptured and unruptured intracranial aneurysms: is it a predisposing factor for rupture risk?Medical science monitor : international medical journal of experimental and clinical research · 2013Article
- Impaired renal function impacts negatively on vascular stiffness in patients with coronary artery disease.BMC nephrology · 2013Article
- Role of genetic changes in the progression of cardiovascular diseases.International journal of biomedical science : IJBS · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMen with coronary artery disease (CAD) have been shown to have enhanced arterial stiffness. Arterial function may change over time according to treatment, but the prognostic value of these changes has not been investigated.
objectivesThe aim of the present study was to assess whether an improvement in large artery rigidity in response to treatment, could predict a more favorable prognosis in a population of men with CAD.
methodsA total of 161 men with CAD (mean age 56.8 ± 10.9 years) being treated with conventional therapy underwent brachial-ankle pulse wave velocity (PWVba) measurements at baseline and after six months. Follow-up period was 3.5 years. End-points were major adverse cardiac events (MACE): acute myocardial infarction, unstable angina, coronary intervention, or cardiac death.
resultsDuring the three-year follow-up period (since initial six-month follow-up), 30 patients experienced MACE. After six-month follow-up, PWVba had not improved (ΔPWVba ≥ 0%, relative to baseline) in 85 (52.8%) of 161 men (Group 1), whereas it had improved (ΔPWVba < 0%) in the remaining 76 men (47.2%) (Group 2). During follow-up, we noticed 24 cardiovascular events in Group 1 and six events in Group 2 (P < 0.001). Cox proportional hazards analyses demonstrated that independent of conventional risk factor changes, absence of PWVba decrease was a predictor of MACE (RR 3.99; 95% CI:1.81-8.78; P = 0.004). The sensitivity of ΔPWVba was 80% and its specificity was 54%.
conclusionsThis study demonstrates that an improvement in arterial stiffness may be obtained after six months of conventional therapy and clearly identifies patients who have a more favorable prognosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.