ArticleJournal of clinical hypertension (Greenwich, Conn.)2011
Big mother or small baby: which predicts hypertension?
Article in Journal of clinical hypertension (Greenwich, Conn.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Maternal overnutrition elevates offspring's blood pressure-A systematic review and meta-analysis.Paediatric and perinatal epidemiology · 2022Pooled it
- The Impact of Maternal Obesity on Offspring Cardiovascular Health: A Systematic Literature Review.Frontiers in endocrinology · 2022Pooled it
- Maternal prepregnancy BMI or weight and offspring's blood pressure: Systematic review.Maternal & child nutrition · 2018Pooled it
- Pre-pregnancy parental BMI and offspring blood pressure in infancy.European journal of preventive cardiology · 2019Trial
- Pregnancy in obese women and mechanisms of increased cardiovascular risk in offspring.European heart journal · 2024Review
- The Influence of Maternal Condition on Fetal Cardiac Function during the Second Trimester.Diagnostics (Basel, Switzerland) · 2023Article
- What to do with kidney length and volumes in large individuals?Pediatric nephrology (Berlin, Germany) · 2023Article
- Urinary KIM-1 is not correlated with gestational age among 5-year-old children born prematurely.Frontiers in pediatrics · 2023Article
- Programming by maternal obesity: a pathway to poor cardiometabolic health in the offspring.The Proceedings of the Nutrition Society · 2022Review
- Oxidative Stress-Induced Hypertension of Developmental Origins: Preventive Aspects of Antioxidant Therapy.Antioxidants (Basel, Switzerland) · 2022Review
- Late referrals of pediatric patients with elevated blood pressure.Pediatric nephrology (Berlin, Germany) · 2020Article
- Prevalence and Risk Factors of Childhood Hypertension in Urban-Rural Areas of China: A Cross-Sectional Study.International journal of hypertension · 2020Article
- U-shaped relationship between birth weight and childhood blood pressure in China.BMC pediatrics · 2019Article
- Developmental Programming of Renal Function and Re-Programming Approaches.Frontiers in pediatrics · 2018Review
- Renal consequences of preterm birth.Molecular and cellular pediatrics · 2017Review
- Association between high birth weight and hypertension in children and adolescents: a cross-sectional study in China.Journal of human hypertension · 2017Article
- Central role for melanocortin-4 receptors in offspring hypertension arising from maternal obesity.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Could Low Birth Weight be Associated with Cardiovascular Disease in Adolescence?Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2016Article
- Reprogramming: A Preventive Strategy in Hypertension Focusing on the Kidney.International journal of molecular sciences · 2015Review
- Programming of Essential Hypertension: What Pediatric Cardiologists Need to Know.Pediatric cardiology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
According to the Barker hypothesis, intrauterine growth restriction and premature delivery adversely affect cardiovascular health in adult life. The association of childhood hypertension as a cardiovascular risk factor and birth weight has been understudied. In a prospective cohort study, the authors evaluated the effect of birth weight, gestational age, maternal prepregnancy body mass index (BMI), and child BMI z score at the time of enrollment on the systolic and diastolic blood pressure (BP) z score in 3024 (1373 women) consecutive outpatient clinic patients aged 2.05 to 18.58 years. The latest National Health and Nutrition Examination Survey (NHANES III) was used to calculate the age-dependent z scores. The median z scores of BMI (+0.48, range -6.96-6.64), systolic BP (+0.41, range -4.50-6.73), and diastolic BP (+0.34, range -3.15-+6.73) were all significantly greater than the NHANES III reference population. Systolic BP z score did not correlate with birth weight or gestational age, but did correlate with maternal prepregnancy BMI (r=.090, P<.0001) and BMI z score (r=.209, P<.0001). Diastolic BP z score positively correlated with birth weight (0.037, P=.044), gestational age (r=.052, P=.005), BMI z score(r=.106, P<.0001), and maternal prepregnancy BMI (r=.062, P=.0007). In contrast to what would be expected from the Barker hypothesis, the authors found no negative correlation between BP z score and birth weight or gestational age. This study suggests that a high BMI, a big mom, and a high birth weight are more important risk factors for hypertension during childhood than low birth weight or gestational age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.