Evidence map›Paper›PMID 21255741›Full record

ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2011

Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 1.

Richard Mayeux, Christiane Reitz, Adam M Brickman, Mary N Haan, Jennifer J Manly, M Maria Glymour, Christopher C Weiss, Kristine Yaffe, Laura Middleton, Hugh C Hendrie and 5 more

Abstract readReview
In one paragraph

Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Review
  7. Medicaid Contributes Substantial Costs to Dementia Care in an Ethnically Diverse Community.The journals of gerontology. Series B, Psychological sciences and social sciences · 2020
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Two-stage screening for early dementia in primary care.Journal of clinical and experimental neuropsychology · 2016
    Article
  13. New Genetic Approaches to AD: Lessons from APOE-TOMM40 Phylogenetics.Current neurology and neuroscience reports · 2016
    Review
  14. Review
  15. Article
  16. Review
  17. Orthostatic hypotension and cognitive impairment: a dangerous association?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014
    Review
  18. Article
  19. Diagnostic accuracy of markers for prodromal Alzheimer's disease in independent clinical series.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2013
    Article
  20. Biomarkers of Alzheimer's disease among Mexican Americans.Journal of Alzheimer's disease : JAD · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 2 countries.

Richard MayeuxGertrude H. Sergievsky Center, Columbia University, New York, NY, USA. rpm2@columbia.edu
Christiane Reitz
Adam M Brickman
Mary N Haan
Jennifer J Manly
M Maria Glymour
Christopher C Weiss
Kristine Yaffe
Laura Middleton
Hugh C Hendrie
Lauren H Warren
Kathleen M Hayden
Kathleen A Welsh-Bohmer
John C S Breitner
John C Morris
Columbia University · USDuke Medical Center · USDouglas Mental Health University Institute · CAHarvard University · USHeart and Stroke Foundation · CARegenstrief Institute · USSan Francisco VA Medical Center · USUniversity of California, San Francisco · USWashington University in St. Louis · US

Funding

WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI CIRRITO, JOHN R · 1985 to 2019
$52.1M
VASCULAR FACTORS AND MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASEP01AG007232 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI LUCHSINGER, JOSE ALEJANDRO · 1989 to 2008
$21.7M
INDIANAPOLIS/IBADAN DEMENTIA PROJECTR01AG009956 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI HALL, KATHLEEN S · 1991 to 2010
$14.0M
EPIDEMIOLOGY OF FUNCTIONAL STATUS IN ELDERLY HISPANICSR01AG012975 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAAN, MARY N · 1997 to 2015
$13.8M
EPIDEMIOLOGY OF DEMENTIA IN CACHE COUNTY, UTAHR01AG011380 · NIA · JOHNS HOPKINS UNIVERSITY · PI WELSH-BOHMER, KATHLEEN ANNE · 1994 to 2009
$12.2M
NEUROPATHOLOGY COREP30AG028377 · NIA · DUKE UNIVERSITY · PI WELSH-BOHMER, KATHLEEN ANNE · 2006 to 2011
$9.6M
COGNITIVE TEST PERFORMANCE OF AFRICAN AMERICAN ELDERSR01AG016206 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MANLY, JENNIFER JAIE · 1999 to 2008
$2.9M
White matter hyperintensities in Aging and DementiaR01AG034189 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M · 2010 to 2014
$2.0M
Cognitive Endophenotypes for Genetic Studies of Alzheimer's DiseaseK01AG029336 · NIA · DUKE UNIVERSITY · PI HAYDEN, KATHLEEN M · 2007 to 2011
$588k
NIA NIH HHS K01 AG029336NIA NIH HHS K01AG029336NIA NIH HHS P01 AG007232NIA NIH HHS P01AG007232NIA NIH HHS P30 AG028377NIA NIH HHS P30AG028377NIA NIH HHS P50 AG005681NIA NIH HHS P50AG05681NIA NIH HHS R01 AG009956NIA NIH HHS R01AG009956NIA NIH HHS R01 AG011380NIA NIH HHS R01AG011380NIA NIH HHS R01 AG012975NIA NIH HHS R01AG012975NIA NIH HHS R01 AG016206NIA NIH HHS R01AG016206NIA NIH HHS R01 AG034189
6 · The paper itself

Abstract

In this article, the challenges faced by several noted population studies for Alzheimer dementia in operationalizing current clinical diagnostic criteria for Alzheimer's disease (AD) have been reviewed. Differences in case ascertainment, methodological biases, cultural and educational influences on test performance, inclusion of special populations such as underrepresented minorities and the oldest old, and detection of the earliest symptomatic stages of underlying AD have been considered. Classification of Alzheimer dementia may be improved by the incorporation of biomarkers for AD if the sensitivity, specificity, and predictive value of the biomarkers are established and if they are appropriate for epidemiological studies, as may occur should a plasma biomarker be developed. Biomarkers for AD could also facilitate studies of the interactions of various forms of neurodegenerative disorders with cerebrovascular disease, resulting in "mixed dementia".

Indexed as

AgingAge FactorsAlzheimer DiseaseBiomarkersCerebrovascular DisordersCognition DisordersCommunity Health PlanningDiagnostic and Statistical Manual of Mental DisordersDiagnostic Techniques and ProceduresHumansNeuropsychological TestsBiomarkers

Identifiers

PMID21255741
PMCPMC3063444
OpenAlexW2915777197

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.