Evidence map›Paper›PMID 21270271›Full record

Trial reportDiabetes2011

Progression of carotid artery intima-media thickness during 12 years in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study.

Joseph F Polak, Jye-Yu C Backlund, Patricia A Cleary, Anita P Harrington, Daniel H O'Leary, John M Lachin, David M Nathan, DCCT/EDIC Research Group

Registry-linked trialOpen access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04614623 (Defining the Role of Management Factors in Outcome Disparity in Pediatric T1D), which is not on this map. Cited by 59 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 3 pooled it
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04614623 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Defining the Role of Management Factors in Outcome Disparity in Pediatric T1D

TypeinterventionalSponsorChildren's Hospital New Orleans, LARan2020 to 2022Enrolled120ConditionsType1diabetesArmsAHCL pump, Video conferencing Application
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 3 syntheses or guidelines pooled it, 126 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Glucose targets for preventing diabetic kidney disease and its progression.The Cochrane database of systematic reviews · 2017
    Pooled it
  4. Trial
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  13. Review
  14. Article
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  18. RISK FACTORS FOR HEARING IMPAIRMENT IN TYPE 1 DIABETES.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2019
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Joseph F PolakTufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA.
Jye-Yu C Backlund
Patricia A Cleary
Anita P Harrington
Daniel H O'Leary
John M Lachin
David M Nathan
DCCT/EDIC Research Group
George Washington University · USTufts Medical Center · USHarvard University · USTufts University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study investigated the long-term effects of intensive diabetic treatment on the progression of atherosclerosis, measured as common carotid artery intima-media thickness (IMT). RESEARCH DESIGN AND

methodsA total of 1,116 participants (52% men) in the Epidemiology of Diabetes Interventions and Complications (EDIC) trial, a long-term follow-up of the Diabetes Control and Complications Trial (DCCT), had carotid IMT measurements at EDIC years 1, 6, and 12. Mean age was 46 years, with diabetes duration of 24.5 years at EDIC year 12. Differences in IMT progression between DCCT intensive and conventional treatment groups were examined, controlling for clinical characteristics, IMT reader, and imaging device.

resultsCommon carotid IMT progression from EDIC years 1 to 6 was 0.019 mm less in intensive than in conventional (P < 0.0001), and from years 1 to 12 was 0.014 mm less (P = 0.048); but change from years 6 to 12 was similar (intensive - conventional = 0.005 mm, P = 0.379). Mean A1C levels during DCCT and DCCT/EDIC were strongly associated with progression of IMT, explaining most of the differences in IMT progression between DCCT treatment groups. Albuminuria, older age, male sex, smoking, and higher systolic blood pressure were significant predictors of IMT progression.

conclusionsIntensive treatment slowed IMT progression for 6 years after the end of DCCT but did not affect IMT progression thereafter (6-12 years). A beneficial effect of prior intensive treatment was still evident 13 years after DCCT ended. These differences were attenuated but not negated after adjusting for blood pressure. These results support the early initiation and continued maintenance of intensive diabetes management in type 1 diabetes to retard atherosclerosis.

Indexed as

Disease ProgressionAdolescentAdultBlood PressureCarotid ArteriesChi-Square DistributionDiabetes ComplicationsDiabetes Mellitus, Type 1FemaleHumansLinear ModelsLongitudinal StudiesMaleMiddle AgedPrognosisSex Factors

Identifiers

PMID21270271
PMCPMC3028362
OpenAlexW2132095884

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.