ReviewProceedings. Biological sciences2011
The evolutionary biology of child health.
Review in Proceedings. Biological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Predicting Body Weight from Birth to Old Age in Giant Pandas Using Machine Learning.Animals : an open access journal from MDPI · 2024Article
- Kin selection as a modulator of human handedness: sex-specific, parental and parent-of-origin effects.Evolutionary human sciences · 2024Article
- The geometry of evolutionary conflict.Proceedings. Biological sciences · 2023Article
- A database of pediatric drug effects to evaluate ontogenic mechanisms from child growth and development.Med (New York, N.Y.) · 2022Article
- No population left behind: Improving paediatric drug safety using informatics and systems biology.British journal of clinical pharmacology · 2022Review
- Evaluating risk detection methods to uncover ontogenic-mediated adverse drug effect mechanisms in children.BioData mining · 2021Article
- Mental Health, Mitochondria, and the Battle of the Sexes.Biomedicines · 2021Review
- Why and How Imprinted Genes Drive Fetal Programming.Frontiers in endocrinology · 2019Article
- Diurnal Cortisol Concentrations and Growth Indexes of 12- to 48-Month-Old Children From Mexico City.The Journal of clinical endocrinology and metabolism · 2018Article
- Paternally Inherited DLK1 Deletion Associated With Familial Central Precocious Puberty.The Journal of clinical endocrinology and metabolism · 2017Article
- The mini-driver model of polygenic cancer evolution.Nature reviews. Cancer · 2015Review
- Maternal-fetal conflict, genomic imprinting and mammalian vulnerabilities to cancer.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Genomic conflicts and sexual antagonism in human health: insights from oxytocin and testosterone.Evolutionary applications · 2015Review
- Adaptive variability in the duration of critical windows of plasticity: Implications for the programming of obesity.Evolution, medicine, and public health · 2014Review
- First principles of Hamiltonian medicine.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Article
- A changing trend in eruption age and pattern of first deciduous tooth: correlation to feeding pattern.Journal of clinical and diagnostic research : JCDR · 2014Article
- The insectan apes.Human nature (Hawthorne, N.Y.) · 2014Article
- Medical, ethical and personal dimensions of parent-offspring conflicts.Evolution, medicine, and public health · 2014Article
- Evolutionary medicine: its scope, interest and potential.Proceedings. Biological sciences · 2012Review
- Genetic Regulation of Puberty Timing in Humans.NeuroendocrinologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
I apply evolutionary perspectives and conceptual tools to analyse central issues underlying child health, with emphases on the roles of human-specific adaptations and genomic conflicts in physical growth and development. Evidence from comparative primatology, anthropology, physiology and human disorders indicates that child health risks have evolved in the context of evolutionary changes, along the human lineage, affecting the timing, growth-differentiation phenotypes and adaptive significance of prenatal stages, infancy, childhood, juvenility and adolescence. The most striking evolutionary changes in humans are earlier weaning and prolonged subsequent pre-adult stages, which have structured and potentiated maladaptations related to growth and development. Data from human genetic and epigenetic studies, and mouse models, indicate that growth, development and behaviour during pre-adult stages are mediated to a notable degree by effects from genomic conflicts and imprinted genes. The incidence of cancer, the primary cause of non-infectious childhood mortality, mirrors child growth rates from birth to adolescence, with paediatric cancer development impacted by imprinted genes that control aspects of growth. Understanding the adaptive significance of child growth and development phenotypes, in the context of human-evolutionary changes and genomic conflicts, provides novel insights into the causes of disease in childhood.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.