ArticleJournal of clinical research in pediatric endocrinology2008
Atherogenic lipid profile and systolic blood pressure are associated with carotid artery intima-media thickness in children with Turner syndrome.
Article in Journal of clinical research in pediatric endocrinology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Are Young People with Turner Syndrome Who Have Undergone Treatment with Growth and Sex Hormones at Higher Risk of Metabolic Syndrome and Its Complications?Biomedicines · 2024Article
- Carotid Intima-Media Thickness and Cardiometabolic Profile in Turner Syndrome: A Cross-Sectional Study.Cureus · 2024Article
- A single-center's uric acid profile in girls with Turner syndrome.Frontiers in endocrinology · 2024Observational
- Components of the metabolic syndrome in girls with Turner syndrome treated with growth hormone in a long term prospective study.Frontiers in endocrinology · 2023Article
- The Cutoff of Gonadotropins for Close Evaluation of Cardiometabolic Risk Factors in Turner Syndrome.International journal of preventive medicine · 2022Article
- Physical Activity and Diet Quality: Effects on Cardiovascular Morbidity in Women with Turner Syndrome-Results from an Online Patient Survey.Journal of clinical medicine · 2021Article
- Monosomy X in Female Mice Influences the Regional Formation and Augments the Severity of Angiotensin II-Induced Aortopathies.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- Insulin Sensitivity and Pancreatic β-Cell Function in Ecuadorian Women With Turner Syndrome.Frontiers in endocrinology · 2020Article
- Cardiometabolic health in Turner syndrome.American journal of medical genetics. Part C, Seminars in medical genetics · 2019Review
- Anthropometric variables as cardiovascular risk predictors in a cohort of adult subjects with Turner syndrome.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- The Natural History of Metabolic Comorbidities in Turner Syndrome from Childhood to Early Adulthood: Comparison between 45,X Monosomy and Other Karyotypes.Frontiers in endocrinology · 2018Article
- Can Brain Natriuretic Peptides and Osteoprotegerin Serve As Biochemical Markers for the Detection of Aortic Pathology in Children and Adolescents with Turner Syndrome?Frontiers in endocrinology · 2017Review
- Effects of aortic irregularities on blood flow.Biomechanics and modeling in mechanobiology · 2016Article
- Cardiometabolic and vascular risks in young and adolescent girls with Turner syndrome.BBA clinical · 2015Review
- Ambulatory blood pressure and subclinical cardiovascular disease in children with turner syndrome.Pediatric cardiology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWomen with Turner syndrome (TS) have greater carotid artery intima-media thickness (cIMT) known to be a risk factor for atherosclerosis in adults. To determine whether there are risk factors for atherosclerosis in children with TS, we compared cIMT, anthropometric and metabolic parameters between children with TS and healthy controls.
methodsData of children with TS with XO karyotype (n=24, mean age: 11.6±3.6) were compared with those of healthy children (n=24, mean age: 10.5±3.6) with respect to anthropometric parameters, lipid levels, insulin resistance and cIMT which was measured by high resolution B-mode ultrasonography.
resultsMean age and cIMT values were similar in the two groups of children. However in children with TS, fasting glucose (p=0.01), total cholesterol (p=0.006), triglyceride (p=0.04) levels and HDL-cholesterol (p=0.002) levels were higher than those of controls. In the TS group, cIMT correlated positively with LDL-cholesterol (r=0.435, p=0.034) and with systolic blood pressure (r=0.430, p=0.036) and negatively with HDL-cholesterol (r=-0.518, p=0.01). In stepwise regression analysis, HDL-cholesterol emerged as a significant predictor of cIMT (b= -0.518, p=0.01) contributing to 26.8 % of its variability.
conclusionThe systolic blood pressure and dyslipidaemia were shown to be risk factors for atherosclerosis in children with TS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.