ArticleBulletin of the World Health Organization2011
High total serum cholesterol, medication coverage and therapeutic control: an analysis of national health examination survey data from eight countries.
Article in Bulletin of the World Health Organization, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04862962 (Retrospective Study to Evaluate the Safety of the Fixed-dose Combination Rosuvastatin / Ezetimibe as a Treatment for Patients With Dyslipidaemia in Usual Medical Practice.), which is not on this map. Cited by 55 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Retrospective Study to Evaluate the Safety of the Fixed-dose Combination Rosuvastatin / Ezetimibe as a Treatment for Patients With Dyslipidaemia in Usual Medical Practice.
Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 152 citations in OpenAlex.
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- Are interventions to increase the uptake of screening for cardiovascular disease risk factors effective? A systematic review and meta-analysis.BMC family practice · 2017Pooled it
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- Differential association of docosahexaenoic and eicosapentaenoic acids with carotid intima-media thickness.Stroke · 2011Trial
- Age- and sex-specific reference values for plasma lipids and lipoproteins in thai adults: a national health examination survey analysis.Journal of health, population, and nutrition · 2025Article
- Understanding community health workers' readiness to provide hyperlipidemia-related self-management support in rural Nepal: a biphasic mixed-methods evaluation.BMC health services research · 2025Article
- The Economic Burden of Atherosclerotic Cardiovascular Disease in the Kingdom of Saudi Arabia.Saudi medical journal · 2025Article
- Effectiveness and Safety of Very-Low-Dose Rosuvastatin-Ezetimibe Therapy in Korean Patients with Dyslipidaemia: A Multicentre Prospective Observational Study.Clinical drug investigation · 2025Observational
- Patterns of type 2 diabetes risk factors using latent class analysis (LCA) model: a population-based study in the South of Iran, Kharameh cohort population.BMC public health · 2025Article
- Patterns of risk factors for cardiovascular diseases in Kheramah PERSION cohort population using a latent class analysis.Scientific reports · 2025Article
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- Cost-Effectiveness Analysis of Evolocumab in Adult Patients with Atherosclerotic Cardiovascular Disease in Canada.Advances in therapy · 2022Article
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- Phyto-Enrichment of Yogurt to Control Hypercholesterolemia: A Functional Approach.Molecules (Basel, Switzerland) · 2022Review
- Cost-Effectiveness Analysis of Evolocumab for the Treatment of Dyslipidemia in the Kingdom of Saudi Arabia.PharmacoEconomics - open · 2022Article
- Real-World Evidence Evaluation on the Lipid Profile, Therapeutic Goals, and Safety of the Fixed-Dose Combination of Rosuvastatin/Ezetimibe (Trezete®) in Dyslipidemia Patients.Cardiology research and practice · 2022Article
- Effects of lipid-lowering treatment intensity and adherence on cardiovascular outcomes in patients with a recent myocardial infarction: a Swedish register-based study.Upsala journal of medical sciences · 2022Observational
- Unmet need for hypercholesterolemia care in 35 low- and middle-income countries: A cross-sectional study of nationally representative surveys.PLoS medicine · 2021Article
- Cardiovascular Event Rates After Myocardial Infarction or Ischaemic Stroke in Patients with Additional Risk Factors: A Retrospective Population-Based Cohort Study.Advances in therapy · 2021Article
- White matter hyperintensity in different migraine subtypes.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
objectiveTo determine the fraction of individuals with high total serum cholesterol who get diagnosed and effectively treated in eight high- and middle-income countries.
methodsUsing data from nationally representative health examination surveys conducted in 1998-2007, we studied a probability sample of 79 039 adults aged 40-79 years from England, Germany, Japan, Jordan, Mexico, Scotland, Thailand and the United States of America. For each country we calculated the prevalence of high total serum cholesterol (total serum cholesterol ≥ 6.2 mmol/l or ≥ 240 mg/dl) and the mean total serum cholesterol level. We also determined the fractions of individuals being diagnosed, treated with cholesterol-lowering medication and effectively controlled (total serum cholesterol < 6.2 mmol/l or < 240 mg/dl).
findingsThe proportion of undiagnosed individuals was highest in Thailand (78%; 95% confidence interval, CI: 74-82) and lowest in the United States (16%; 95% CI: 13-19). The fraction diagnosed but untreated ranged from 9% in Thailand (95% CI: 8-11) to 53% in Japan (95% CI: 50-57). The proportion being treated who had attained evidence of control ranged from 4% in Germany (95% CI: 3-5) to 58% in Mexico (95% CI: 54-63). Time series estimates showed improved control of high total serum cholesterol over the past two decades in England and the United States.
conclusionThe percentage of people with high total serum cholesterol who are effectively treated remains small in selected high- and middle-income countries. Many of those affected are unaware of their condition. Untreated high blood cholesterol represents a missed opportunity in the face of a global epidemic of chronic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.