SynthesisJournal of the American Society of Nephrology : JASN2011
CUBN is a gene locus for albuminuria.
Open access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in Journal of the American Society of Nephrology : JASN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 12 of them syntheses that pooled it.
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132citing papers in PubMed, 12 pooled it
14.5field-weighted citation impact, top 1% of its field
What it found
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Who cites it
132 citing papers in PubMed, 12 syntheses or guidelines pooled it, 235 citations in OpenAlex.
- Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.Communications biology · 2022Pooled it
- Confirmation of GLRA3 as a susceptibility locus for albuminuria in Finnish patients with type 1 diabetes.Scientific reports · 2018Pooled it
- Novel risk genes identified in a genome-wide association study for coronary artery disease in patients with type 1 diabetes.Cardiovascular diabetology · 2018Pooled it
- A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.PloS one · 2018Pooled it
- Pooled it
- Genetic studies of body mass index yield new insights for obesity biology.Nature · 2015 · on this mapPooled it
- Pooled it
- Genome-wide meta-analyses of plasma renin activity and concentration reveal association with the kininogen 1 and prekallikrein genes.Circulation. Cardiovascular genetics · 2015Pooled it
- Common variants in Mendelian kidney disease genes and their association with renal function.Journal of the American Society of Nephrology : JASN · 2013Pooled it
- Overlap between common genetic polymorphisms underpinning kidney traits and cardiovascular disease phenotypes: the CKDGen consortium.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2013Pooled it
- Genome-wide association and functional follow-up reveals new loci for kidney function.PLoS genetics · 2012Pooled it
- Genetic association for renal traits among participants of African ancestry reveals new loci for renal function.PLoS genetics · 2011Pooled it
- Genetic variants for prediction of gestational diabetes mellitus and modulation of susceptibility by a nutritional intervention based on a Mediterranean diet.Frontiers in endocrinology · 2022Trial
- Human C-terminal CUBN variants associate with chronic proteinuria and normal renal function.The Journal of clinical investigation · 2020Trial
- Kidney disease and related findings in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study.Diabetes care · 2014Trial
- Biomarkers in Diabetic Kidney Disease: Early Detection, Prognostic Assessment, and Integration with Multi-Omics Signatures.Life (Basel, Switzerland) · 2026Review
- Urinary biomarkers of diabetic kidney disease.World journal of diabetes · 2026Review
- A Pilot Study of Urinary Cubilin Shedding in Type 1 Diabetes Mellitus: A Potential Biomarker to Predict Nephropathy.Journal of diabetes research · 2026Article
- Tubular proteinuria due to hereditary endocytic receptor disorder of the proximal tubule: Dent disease and chronic benign proteinuria.Pediatric nephrology (Berlin, Germany) · 2025Review
- Microbiota-derived corisin accelerates kidney fibrosis by promoting cellular aging.Nature communications · 2025Article
72 more citing papers are in PubMed but not listed here.
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Authors and funding
116 authors at 20 institutions in 11 countries.
Carsten A BögerDepartment of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.
Ming-Huei Chen
Adrienne Tin
Matthias Olden
Anna Köttgen
Ian H de Boer
Christian Fuchsberger
Conall M O'Seaghdha
Cristian Pattaro
Alexander Teumer
Ching-Ti Liu
Nicole L Glazer
Man Li
Jeffrey R O'Connell
Toshiko Tanaka
Carmen A Peralta
Zoltán Kutalik
Jian'an Luan
Jing Hua Zhao
Shih-Jen Hwang
Ermeg Akylbekova
Holly Kramer
Pim van der Harst
Albert V Smith
Kurt Lohman
Mariza de Andrade
Caroline Hayward
Barbara Kollerits
Anke Tönjes
Thor Aspelund
Erik Ingelsson
Gudny Eiriksdottir
Lenore J Launer
Tamara B Harris
Alan R Shuldiner
Braxton D Mitchell
Dan E Arking
Nora Franceschini
Eric Boerwinkle
Josephine Egan
Dena Hernandez
Muredach Reilly
Raymond R Townsend
Thomas Lumley
David S Siscovick
Bruce M Psaty
Bryan Kestenbaum
Talin Haritunians
Sven Bergmann
Peter Vollenweider
Gerard Waeber
Vincent Mooser
Dawn Waterworth
Andrew D Johnson
Jose C Florez
James B Meigs
Xiaoning Lu
Stephen T Turner
Elizabeth J Atkinson
Tennille S Leak
Knut Aasarød
Frank Skorpen
Ann-Christine Syvänen
Thomas Illig
Jens Baumert
Wolfgang Koenig
Bernhard K Krämer
Olivier Devuyst
Josyf C Mychaleckyj
Cosetta Minelli
Stephan J L Bakker
Lyudmyla Kedenko
Bernhard Paulweber
Stefan Coassin
Karlhans Endlich
Heyo K Kroemer
Reiner Biffar
Sylvia Stracke
Henry Völzke
Michael Stumvoll
Reedik Mägi
Harry Campbell
Veronique Vitart
Nicholas D Hastie
Vilmundur Gudnason
Sharon L R Kardia
Yongmei Liu
Ozren Polasek
Gary Curhan
Florian Kronenberg
Inga Prokopenko
Igor Rudan
Johan Arnlöv
Stein Hallan
Gerjan Navis
CKDGen Consortium
Afshin Parsa
Luigi Ferrucci
Josef Coresh
Michael G Shlipak
Shelley B Bull
Nicholas J Paterson
H-Erich Wichmann
Nicholas J Wareham
Ruth J F Loos
Jerome I Rotter
Peter P Pramstaller
L Adrienne Cupples
Jacques S Beckmann
Qiong Yang
Iris M Heid
Rainer Rettig
Albert W Dreisbach
Murielle Bochud
Caroline S Fox
W H L Kao
Boston University · USJohns Hopkins University · USNational Institutes of Health · USHarvard University Press · USUniversity of Lausanne · CHInnsbruck Medical University · ATNorwegian University of Science and Technology · NOSeattle University · USUniversity of Baltimore · USUniversity of Edinburgh · GBUniversity of Groningen · NLUniversity of Iceland · ISUniversity of Regensburg · DEWinnMed · USCedars-Sinai Medical Center · USGlaxoSmithKline (United Kingdom) · GBLeipzig University · DESIB Swiss Institute of Bioinformatics · CHUniversity of California, San Francisco · USUniversity of Toronto · CA
Funding
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, TAMIMI, RULLA M · 2000 to 2019
$77.8MInstitute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MZONA-FREE HAMSTER OVA ASSAY AS AN INDICATOR OF MALE FERTILITYM01RR000425 · NCRR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI WANG, CHRISTINA C. · 1985 to 2011
$74.2MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4MRisk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3MZosuquidar trihydrochloride for acute myeloid leukemia &refractory anemiaM01RR000080 · NCRR · UNIVERSITY HOSPITALS OF CLEVELAND · PI DEARBORN, DORR GELLATLY · 1985 to 2007
$22.2MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MIDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6MZonulin Antibodies in Intestinal Permeabilitiy in IDDMM01RR016500 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI EDELMAN, MARTIN J. · 2002 to 2009
$20.2MResearch BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D · 2005 to 2019
$17.3MClinical Research Career Development (RMI)K12RR023250 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI SHULDINER, ALAN R. · 2005 to 2009
$13.3MCell Interactions in the Inflamed Intestinal MucosaR01DK075787 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI JOEL N HIRSCHHORN · 2007 to 2026
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DK066574NIDDK NIH HHS R01 DK075787NIDDK NIH HHS R01 DK077510NIDDK NIH HHS R01-DK-077510NIDDK NIH HHS T32 DK007791NIGMS NIH HHS U01 GM074518NIGMS NIH HHS U01 GM074518-04Wellcome Trust
Abstract
Identification of genetic risk factors for albuminuria may alter strategies for early prevention of CKD progression, particularly among patients with diabetes. Little is known about the influence of common genetic variants on albuminuria in both general and diabetic populations. We performed a meta-analysis of data from 63,153 individuals of European ancestry with genotype information from genome-wide association studies (CKDGen Consortium) and from a large candidate gene study (CARe Consortium) to identify susceptibility loci for the quantitative trait urinary albumin-to-creatinine ratio (UACR) and the clinical diagnosis microalbuminuria. We identified an association between a missense variant (I2984V) in the CUBN gene, which encodes cubilin, and both UACR (P = 1.1 × 10(-11)) and microalbuminuria (P = 0.001). We observed similar associations among 6981 African Americans in the CARe Consortium. The associations between this variant and both UACR and microalbuminuria were significant in individuals of European ancestry regardless of diabetes status. Finally, this variant associated with a 41% increased risk for the development of persistent microalbuminuria during 20 years of follow-up among 1304 participants with type 1 diabetes in the prospective DCCT/EDIC Study. In summary, we identified a missense CUBN variant that associates with levels of albuminuria in both the general population and in individuals with diabetes.
Indexed as
AlbuminuriaBlack or African AmericanBlack PeopleGenetic LociGenetic Predisposition to DiseaseHumansMutation, MissenseReceptors, Cell SurfaceWhite Peopleintrinsic factor-cobalamin receptorReceptors, Cell Surface
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