Evidence map›Paper›PMID 21373204›Full record

ReviewExpert review of clinical pharmacology2011

Hydrogen sulfide-mediated myocardial pre- and post-conditioning.

Benjamin L Predmore, David J Lefer

Abstract readReview
In one paragraph

Review in Expert review of clinical pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Hydrogen Sulfide Donors Activated by Reactive Oxygen Species.Angewandte Chemie (International ed. in English) · 2016
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Hydrogen sulfide in biochemistry and medicine.Antioxidants & redox signaling · 2012
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Benjamin L PredmoreDepartment of Surgery, Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, GA, USA.
David J Lefer

Funding

Cardioprotective Actions of Hydrogen SulfideR01HL092141 · NHLBI · LSU HEALTH SCIENCES CENTER · PI LEFER, DAVID JOSEPH · 2009 to 2013
$1.9M
Nitrite Mediated CardioprotectionR01HL093579 · NHLBI · LSU HEALTH SCIENCES CENTER · PI LEFER, DAVID JOSEPH · 2009 to 2012
$1.5M
NHLBI NIH HHS 1R01 HL093579-01A1NHLBI NIH HHS 5R01 HL092141-02NHLBI NIH HHS R01 HL092141NHLBI NIH HHS R01 HL093579
6 · The paper itself

Abstract

Coronary artery disease is a major cause of morbidity and mortality in the Western world. Acute myocardial infarction, resulting from coronary artery atherosclerosis, is a serious and often fatal consequence of coronary artery disease, resulting in cell death in the myocardium. Pre- and post-conditioning of the myocardium are two treatment strategies that reduce the amount of cell death significantly. Hydrogen sulfide has recently been identified as a potent cardioprotective signaling molecule, which is a highly effective pre- and post-conditioning agent. The cardioprotective signaling pathways involved in hydrogen sulfide-based pre- and post-conditioning will be explored in this article.

Indexed as

Ischemic PostconditioningIschemic Preconditioning, MyocardialAnimalsCardiotonic AgentsCoronary VesselsHumansHydrogen SulfideMyocardial Reperfusion InjuryMyocardiumSignal TransductionCardiotonic AgentsHydrogen Sulfideacute myocardial infarctionapoptosisischemia/reperfusion injurymyocardial protectionoxidative stress

Identifiers

PMID21373204
PMCPMC3045730

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.