ArticleGenome research2011
Genetic analysis of complex traits in the emerging Collaborative Cross.
Article in Genome research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 242 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
242 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis identifies gene-by-environment interactions as demonstrated in a study of 4,965 mice.PLoS genetics · 2014Pooled it
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- Machine vision based frailty assessment for genetically diverse mice.bioRxiv : the preprint server for biology · 2024Article
- Inter-strain variability in responses to a single administration of the cannabidiol-rich cannabis extract in mice.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2024Article
- Genetic loci regulate Sarbecovirus pathogenesis: A comparison across mice and humans.Virus research · 2024Article
- Gene expression variation underlying tissue-specific responses to copper stress in Drosophila melanogaster.G3 (Bethesda, Md.) · 2024Article
- Identifying genetic susceptibility to Aspergillus fumigatus infection using collaborative cross mice and RNA-Seq approach.Animal models and experimental medicine · 2024Article
- Postzygotic barriers persist despite ongoing introgression in hybridizing Mimulus species.Molecular ecology · 2024Article
- Towards system genetics analysis of head and neck squamous cell carcinoma using the mouse model, cellular platform, and clinical human data.Animal models and experimental medicine · 2023Review
- Age-dependent genetic regulation of osteoarthritis: independent effects of immune system genes.Arthritis research & therapy · 2023Article
- Host Genetic Background Effect on Body Weight Changes Influenced by HeterozygousInternational journal of molecular sciences · 2023Article
- Gene expression variation underlying tissue-specific responses to copper stress inbioRxiv : the preprint server for biology · 2023Article
- Lowering fasting blood glucose with non-dialyzable material of cranberry extract is dependent on host genetic background, sex and diet.Animal models and experimental medicine · 2023Article
- Which mouse multiparental population is right for your study? The Collaborative Cross inbred strains, their F1 hybrids, or the Diversity Outbred population.G3 (Bethesda, Md.) · 2023Article
182 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
41 authors.
Funding
Abstract
The Collaborative Cross (CC) is a mouse recombinant inbred strain panel that is being developed as a resource for mammalian systems genetics. Here we describe an experiment that uses partially inbred CC lines to evaluate the genetic properties and utility of this emerging resource. Genome-wide analysis of the incipient strains reveals high genetic diversity, balanced allele frequencies, and dense, evenly distributed recombination sites-all ideal qualities for a systems genetics resource. We map discrete, complex, and biomolecular traits and contrast two quantitative trait locus (QTL) mapping approaches. Analysis based on inferred haplotypes improves power, reduces false discovery, and provides information to identify and prioritize candidate genes that is unique to multifounder crosses like the CC. The number of expression QTLs discovered here exceeds all previous efforts at eQTL mapping in mice, and we map local eQTL at 1-Mb resolution. We demonstrate that the genetic diversity of the CC, which derives from random mixing of eight founder strains, results in high phenotypic diversity and enhances our ability to map causative loci underlying complex disease-related traits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.