ReviewNature reviews. Cancer2011
Testicular germ cell tumours: predisposition genes and the male germ cell niche.
Review in Nature reviews. Cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.Nature genetics · 2013Pooled it
- Mechanisms of cisplatin sensitivity and resistance in testicular germ cell tumors and potential therapeutic agents (Review).Experimental and therapeutic medicine · 2025Review
- The establishment and regulation of human germ cell lineage.Stem cell research & therapy · 2025Review
- Cannabis- and Substance-Related Carcinogenesis in Europe: A Lagged Causal Inferential Panel Regression Study.Journal of xenobiotics · 2023Article
- Epigenetic Regulation of Driver Genes in Testicular Tumorigenesis.International journal of molecular sciences · 2023Review
- State Trends of Cannabis Liberalization as a Causal Driver of Increasing Testicular Cancer Rates across the USA.International journal of environmental research and public health · 2022Article
- Spectrum of Germ Cell Tumor (GCT): 5 Years' Experience in a Tertiary Care Center and Utility of OCT4 as a Diagnostic Adjunct.Indian journal of surgical oncology · 2022Article
- Performance characteristics ofCanadian Urological Association journal = Journal de l'Association des urologues du Canada · 2022Article
- Cannabinoid and substance relationships of European congenital anomaly patterns: a space-time panel regression and causal inferential study.Environmental epigenetics · 2022Article
- Causal inference multiple imputation investigation of the impact of cannabinoids and other substances on ethnic differentials in US testicular cancer incidence.BMC pharmacology & toxicology · 2021Article
- Human germ cell tumours from a developmental perspective.Nature reviews. Cancer · 2019Review
- IGF signalling in germ cells and testicular germ cell tumours: roles and therapeutic approaches.Andrology · 2019Review
- miR-509-5p Downregulation Is Associated With Male Infertility And Acts As A Suppressor In Testicular Germ Cell Tumor Cells Through Targeting MDM2.OncoTargets and therapy · 2019Article
- Loss of heparan sulfate in the niche leads to tumor-like germ cell growth in the Drosophila testis.Glycobiology · 2018Article
- IGF1R signalling in testicular germ cell tumour cells impacts on cell survival and acquired cisplatin resistance.The Journal of pathology · 2018Article
- Testicular germ cell tumor genomics.Current opinion in urology · 2017Review
- T-cell Acute Lymphoblastic Leukemia Cells Display Activation of Different Survival Pathways.Journal of Cancer · 2017Article
- Testicular cancer in two brothers of a quadruplet: a case report and a review of literature.Acta medica Lituanic · 2017Article
- Synchronous bilateral testis cancer: clinical and oncological management.Contemporary oncology (Poznan, Poland) · 2017Article
- RTN3 Regulates the Expression Level of Chemokine Receptor CXCR4 and is Required for Migration of Primordial Germ Cells.International journal of molecular sciences · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Testicular germ cell tumours (TGCTs) of adults and adolescents are putatively derived from primordial germ cells or gonocytes. Recently reported genome-wide association studies implicate six gene loci that predispose to TGCT development. Remarkably, the functions of proteins encoded by genes within these regions bridge our understanding between the pathways involved in primordial germ cell physiology, male germ cell development and the molecular pathology of TGCTs. Furthermore, this improved understanding of the mechanisms underlying TGCT development and dissemination has clinical relevance for the management of patients with these tumours.
Indexed as
Identifiers
21412254What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.