ArticlePrimary care diabetes2011
HbA(1c) values for defining diabetes and impaired fasting glucose in Asian Indians.
Article in Primary care diabetes, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- The changing relationship between HbA1c and FPG according to different FPG ranges.Journal of endocrinological investigation · 2016Trial
- Maturity-Onset Diabetes of the Young (MODY) Presenting With a Diabetic Foot Ulcer: A Case Report.Cureus · 2025Article
- Hyperinsulinemia: an early biomarker of metabolic dysfunction.Frontiers in clinical diabetes and healthcare · 2023Article
- Burden of Type 2 Diabetes and Associated Cardiometabolic Traits and Their Heritability Estimates in Endogamous Ethnic Groups of India: Findings From the INDIGENIUS Consortium.Frontiers in endocrinology · 2022Article
- Optimizing the treatment of newly diagnosed type 2 diabetes mellitus with combination of dipeptidyl peptidase-4 inhibitors and metformin: An expert opinion.Journal of family medicine and primary care · 2021Review
- Effect of Correction of Hyperthyroidism with Anti-thyroid Drugs on the Glycated Hemoglobin in Non-diabetic Patients with Primary Hyperthyroidism.International journal of endocrinology and metabolism · 2021Article
- Pitfalls of HbA1c in the Diagnosis of Diabetes.The Journal of clinical endocrinology and metabolism · 2020Article
- Review of methods for detecting glycemic disorders.Diabetes research and clinical practice · 2020Review
- Glycated hemoglobin (HbA1c) as diagnostic criteria for diabetes: the optimal cut-off points values for the Pakistani population; a study from second National Diabetes Survey of Pakistan (NDSP) 2016-2017.BMJ open diabetes research & care · 2020Article
- Metabolic syndrome is a predictor of decreased renal function among community-dwelling middle-aged and elderly Japanese.International urology and nephrology · 2019Article
- Authors' Response.The Indian journal of medical research · 2017Article
- Derivation & validation of glycosylated haemoglobin (HbAThe Indian journal of medical research · 2016Article
- Management of NCD in low- and middle-income countries.Global heart · 2014Review
- Association between serum endogenous secretory receptor for advanced glycation end products and risk of type 2 diabetes mellitus with combined depression in the Chinese population.Diabetes technology & therapeutics · 2012Article
- Multi-center feasibility study evaluating recruitment, variability in risk factors and biomarkers for a diet and cancer cohort in India.BMC public health · 2011Article
- Comparison of Hemoglobin AIndian journal of endocrinology and metabolismArticle
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Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
Abstract
aimTo determine the glycosylated haemoglobin (HbA(1c)) cut-points for diabetes and impaired fasting glucose (IFG) among Asian Indians.
methodsParticipants (n=525) were a random sample selected from the India Health Study. Based on history and fasting plasma glucose (FPG), participants were classified into known diabetes, newly diagnosed diabetes (NDD), impaired fasting glucose (IFG) [ADA and WHO criteria] or normal fasting glucose (NFG). Receiver Operating Characteristic curves were used to identify the optimum sensitivity and specificity for defining HbA(1c) cut-points for NDD and IFG against the FPG criteria.
resultsThere were 64 participants with a known history of diabetes. Of the remaining 461, IFG was present in 44.7% (ADA) and 18.2% (WHO), and 10.4% were NDD. Mean HbA(1c) were 5.4 (±0.04)% for NFG; 5.7 (±0.06)% among IFG-ADA, 5.8 (±0.09)% among IFG-WHO; 7.5 (±0.33)% for NDD and 8.4 (±0.32)% for known diabetes. Optimal HbA(1c) cut-point for NDD was 5.8% (sensitivity=75%, specificity=75.5%, AUC=0.819). Cut-point for IFG (ADA) was 5.5% (sensitivity=59.7%, specificity=59.9%, AUC=0.628) and for IFG (WHO) was 5.6% (sensitivity=60.7%, specificity=65.1%, AUC=0.671).
conclusionIn this study population from north and south regions of India, the HbA(1c) cut-point that defines NDD (≥5.8%) was much lower than that proposed by an international expert committee and the American Diabetes Association (≥6.5%). A cut-point of ≥5.5% or ≥5.6% defined IFG, and was slightly lower than the ≥5.7% for high risk proposed, but accuracy was less than 70%.
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