Trial reportAtherosclerosis2011
Exercise training increases endothelial progenitor cells and decreases asymmetric dimethylarginine in peripheral arterial disease: a randomized controlled trial.
Trial report in Atherosclerosis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03883412 (Effect of Exercise and/or Liraglutide on Vascular Dysfunction and Insulin Sensitivity in Type 2 Diabetes), which is not on this map. Cited by 52 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Exercise and/or Liraglutide on Vascular Dysfunction and Insulin Sensitivity in Type 2 Diabetes ( ZQL007)
Who cites it
52 citing papers in PubMed, 5 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- A systematic review of exercise intervention reporting quality and dose in studies of intermittent claudication.Vascular · 2023Pooled it
- Network Meta-Analysis Comparing the Outcomes of Treatments for Intermittent Claudication Tested in Randomized Controlled Trials.Journal of the American Heart Association · 2021Pooled it
- Pooled it
- Supervised exercise therapy versus home-based exercise therapy versus walking advice for intermittent claudication.The Cochrane database of systematic reviews · 2018Pooled it
- Exercise for intermittent claudication.The Cochrane database of systematic reviews · 2017Pooled it
- Health Effects of the Programmed Physical Activities on Lipid Profile in Peripheral Arterial Disease of the Lower Extremities.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2015Trial
- Angiogenic response to passive movement and active exercise in individuals with peripheral arterial disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Trial
- Progenitor cell release plus exercise to improve functional performance in peripheral artery disease: the PROPEL Study.Contemporary clinical trials · 2013Trial
- Acute High Intensity Interval Exercise Promotes Circulating Progenitor Cell Mobilization and Improves Microcirculation in Patients with Chronic Heart Failure.Journal of cardiovascular development and disease · 2026Article
- Treatment of endothelial cell dysfunction in atherosclerosis: a new perspective integrating traditional and modern approaches.Frontiers in physiology · 2025Review
- The impact of acute and chronic aerobic and resistance exercise on stem cell mobilization: A review of effects in healthy and diseased individuals across different age groups.Regenerative therapy · 2024Article
- Is It Possible to Train the Endothelium?-A Narrative Literature Review.Life (Basel, Switzerland) · 2024Review
- The Role of Physiotherapy in Peripheral Artery Disease in Patients With Diabetes Mellitus: A Narrative Review.Cureus · 2024Review
- Potential role of endothelial progenitor cells in the pathogenesis and treatment of cerebral aneurysm.Frontiers in cellular neuroscience · 2024Review
- Advancements in the Regulation of Different-Intensity Exercise Interventions on Arterial Endothelial Function.Reviews in cardiovascular medicine · 2023Review
- Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease-Pathophysiology and Translational Therapeutic Approaches.Biomedicines · 2023Review
- Exercise-induced skeletal muscle angiogenesis: impact of age, sex, angiocrines and cellular mediators.European journal of applied physiology · 2023Review
- Aerobically trained older adults show impaired resting, but preserved exercise-induced circulating progenitor cell count, which was not improved by sprint interval training.Pflugers Archiv : European journal of physiology · 2023Article
- Exercise protects vascular function by countering senescent cells in older adults.Frontiers in physiology · 2023Review
- Circulating Endothelial Progenitor and Mesenchymal Stromal Cells as Biomarkers for Monitoring Disease Status and Responses to Exercise.Reviews in cardiovascular medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSupervised exercise training (SET) is recommended as initial treatment to improve walking capacity in peripheral arterial disease (PAD) patients with intermittent claudication. Various mechanisms by which SET yields beneficial effects are postulated, however data regarding its influence on angiogenesis are scarce. Thus, we designed a prospective randomized controlled trial to study the impact of SET on markers of angiogenesis and endothelial function in PAD.
methodsForty PAD patients were randomized to SET on top of best medical treatment (SET+BMT) for 6 months versus best medical treatment (BMT) only. Endothelial progenitor cells (EPC) were assessed by whole-blood flow cytometry (co-expression of CD34+ CD133+ KDR+) and cell culture assays (endothelial cell-colony forming units, circulating angiogenic cells, migration assay) at baseline, 3, 6 and 12-months after inclusion. Changes of plasma levels of asymmetric dimethylarginine (ADMA), vascular endothelial growth factor (VEGF), stromal cell-derived factor-1 (SDF-1) and maximum walking distance were determined.
resultsEPC - measured by flow cytometric and cell culture techniques - increased significantly upon training paralleled by a significant decrease of ADMA when compared to the BMT group (p<0.05). Six months after training cessation, the beneficial effect of SET on EPC diminished, but maximum walking distance was significantly improved compared to baseline and controls (p<0.05). No significant changes were observed for VEGF and SDF-1 plasma levels in time course.
conclusionsSET increases circulating EPC counts and decreases ADMA levels reflecting enhanced angiogenesis and improved endothelial function, which might contribute to cardiovascular risk reduction.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.