Trial reportThe Journal of physiology2011
Human skeletal muscle glycogen utilization in exhaustive exercise: role of subcellular localization and fibre type.
Trial report in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 124 citations in OpenAlex.
- Effects of Low-Carbohydrate and Ketogenic Diets on Anaerobic Performance in Competitive Athletes: A Systematic Review and Meta-Analysis.Nutrients · 2026Pooled it
- Local depletion of glycogen with supramaximal exercise in human skeletal muscle fibres.The Journal of physiology · 2017Trial
- Isokinetic eccentric resistance training prevents loss in mechanical muscle function after running.European journal of applied physiology · 2013Trial
- Graded Carbohydrate Ingestion up to 120 g·hScandinavian journal of medicine & science in sports · 2026Article
- Prolonged running reduces speed at the moderate-to-heavy intensity transition without additional reductions due to increased eccentric load.European journal of applied physiology · 2025Article
- Durability of the Major Determinants of Endurance Performance Is Not Different After 15 kJ·kgEuropean journal of sport science · 2025Article
- Dynamics of muscle glycogen increase in brachial and thigh muscles with carbohydrate loading.European journal of applied physiology · 2025Article
- Carbohydrate ingestion during prolonged exercise blunts the reduction in power output at the moderate-to-heavy intensity transition.European journal of applied physiology · 2025Article
- Individual responses to purple grape juice consumption on endurance, explosive power, and fatigue in young male elite soccer players.Frontiers in nutrition · 2025Article
- Self-reported carbohydrate supercompensation and supplementation strategies adopted by Olympic triathlon athletes.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025Article
- In vivo imaging of glycogen in human muscle.Nature communications · 2024Article
- Mitochondrial Redox Status Regulates Glycogen Metabolism via Glycogen Phosphorylase Activity.Antioxidants (Basel, Switzerland) · 2024Article
- Does AMPK bind glycogen in skeletal muscle or is the relationship correlative?Essays in biochemistry · 2024Review
- Effect of Low vs. High Carbohydrate Intake after Glycogen-Depleting Workout on Subsequent 1500 m Run Performance in High-Level Runners.Nutrients · 2024Article
- Peak Week Carbohydrate Manipulation Practices in Physique Athletes: A Narrative Review.Sports medicine - open · 2024Review
- Carbohydrate Nutrition and Skill Performance in Soccer.Sports medicine (Auckland, N.Z.) · 2023Review
- Exercise metabolism and adaptation in skeletal muscle.Nature reviews. Molecular cell biology · 2023Review
- The molecular athlete: exercise physiology from mechanisms to medals.Physiological reviews · 2023Review
- Fibre type- and localisation-specific muscle glycogen utilisation during repeated high-intensity intermittent exercise.The Journal of physiology · 2022Article
- Specific ATPases drive compartmentalized glycogen utilization in rat skeletal muscle.The Journal of general physiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although glycogen is known to be heterogeneously distributed within skeletal muscle cells, there is presently little information available about the role of fibre types, utilization and resynthesis during and after exercise with respect to glycogen localization. Here, we tested the hypothesis that utilization of glycogen with different subcellular localizations during exhaustive arm and leg exercise differs and examined the influence of fibre type and carbohydrate availability on its subsequent resynthesis. When 10 elite endurance athletes (22 ± 1 years, VO2 max = 68 ± 5 ml kg-1 min-1, mean ± SD) performed one hour of exhaustive arm and leg exercise, transmission electron microscopy revealed more pronounced depletion of intramyofibrillar than of intermyofibrillar and subsarcolemmal glycogen. This phenomenon was the same for type I and II fibres, although at rest prior to exercise, the former contained more intramyofibrillar and subsarcolemmal glycogen than the latter. In highly glycogen-depleted fibres, the remaining small intermyofibrillar and subsarcolemmal glycogen particles were often found to cluster in groupings. In the recovery period, when the athletes received either a carbohydrate-rich meal or only water the impaired resynthesis of glycogen with water alone was associated primarily with intramyofibrillar glycogen. In conclusion, after prolonged high-intensity exercise the depletion of glycogen is dependent on subcellular localization. In addition, the localization of glycogen appears to be influenced by fibre type prior to exercise, as well as carbohydrate availability during the subsequent period of recovery. These findings provide insight into the significance of fibre type-specific compartmentalization of glycogen metabolism in skeletal muscle during exercise and subsequent recovery. .
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.