ArticleInternational journal of cardiology2012
HIV infection and cocaine use induce endothelial damage and dysfunction in African Americans.
Article in International journal of cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 11 citations in OpenAlex.
- A single-blind, randomized, controlled contingency management trial on physiological indices and biomarkers of cardiovascular health in people with cocaine use disorder.Drug and alcohol dependence · 2025Trial
- Analysis of the relationship between the expression of EBV-related antibodies and ET-1 axis in gastric cancer.Cancer biomarkers : section A of Disease markers · 2022Article
- Cocaine use modifies the association between antiretroviral therapy and endothelial dysfunction among adults with HIV infection.Journal of medical virology · 2019Article
- An atypical subacute presentation of posterior reversible encephalopathy syndrome.Journal of community hospital internal medicine perspectives · 2017Article
- Vascular disease in cocaine addiction.Atherosclerosis · 2017Review
- Host factors associated with serologic inflammatory markers assessed using multiplex assays.Cytokine · 2016Article
- Chronic cocaine disrupts neurovascular networks and cerebral function: optical imaging studies in rodents.Journal of biomedical optics · 2016Article
- Article
- Correlates of elevated interleukin-6 and C-reactive protein in persons with or at high risk for HCV and HIV infections.Journal of acquired immune deficiency syndromes (1999) · 2013Article
- Coronary Plaque Progression and Regression in Asymptomatic African American Chronic Cocaine Users With Obstructive Coronary Stenoses: A Preliminary Study.Journal of addiction medicineArticle
- Cocaine Abstinence and Reduced Use Associated With Lowered Marker of Endothelial Dysfunction in African Americans: A Preliminary Study.Journal of addiction medicineArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundClinical and epidemiological evidence suggests that HIV infection and cocaine use are associated with an increased risk of premature atherosclerosis. The underlying mechanisms linking HIV infection and cocaine use with early atherosclerosis remain elusive. METHODS AND
resultsEndothelin-1 (ET-1) levels in 360 African American participants in Baltimore, Maryland were measured. Quantile regression analysis was performed to examine the associations between ET-1, HIV infection, cocaine use, and other relevant clinical factors. The median of ET-1 in plasma, (1.05 pg/mL with interquartile range: 0.73, 1.40) for those with HIV infection was significantly higher than values for those without HIV infection (0.74 pg/mL with interquartile range: 0.61, 0.93). The median of ET-1 was markedly higher in chronic cocaine users (0.96 pg/mL with interquartile range: 0.71, 1.36) than that in non-cocaine users (0.72 pg/mL with interquartile range: 0.58, 1.06). Multivariate quantile regression suggested that HIV infection and duration of cocaine use were independently associated with plasma ET-1 levels after controlling for potential confounding factors.
conclusionsThis study may provide insight into the mechanism of premature atherosclerosis in HIV-infected cocaine users and suggest that measurement of ET-1 in plasma can be used as a marker of early atherosclerosis in HIV infected patients and cocaine users.
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