ArticleProceedings of the National Academy of Sciences of the United States of America1990
Activated type I phosphatidylinositol kinase is associated with the epidermal growth factor (EGF) receptor following EGF stimulation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed, 184 citations in OpenAlex.
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- EGFR-induced lncRNAProceedings of the National Academy of Sciences of the United States of America · 2025Article
- ADAM12 promotes gemcitabine resistance by activating EGFR signaling pathway and induces EMT in bladder cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023Article
- Class I PI3K Biology.Current topics in microbiology and immunology · 2022Article
- Metabolic Rewiring in Radiation Oncology Toward Improving the Therapeutic Ratio.Frontiers in oncology · 2021Review
- Understanding Lineage Plasticity as a Path to Targeted Therapy Failure inFrontiers in genetics · 2020Review
- Epidermal Growth Factor Receptor and Its Role in Pancreatic Cancer Treatment Mediated by Nanoparticles.International journal of nanomedicine · 2019Review
- Zeb1 potentiates genome-wide gene transcription with Lef1 to promote glioblastoma cell invasion.The EMBO journal · 2018Article
- Review
- Regulation of PI3K/Akt dependent apoptotic markers during b virus infection of human and macaque fibroblasts.PloS one · 2017Article
- Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer.BMC cancer · 2016Article
- The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes.Nature communications · 2016Article
- Signal transduction by M3 muscarinic acetylcholine receptor in prostate cancer.Oncology letters · 2016Article
- Where EGF receptors transmit their signals.Science signaling · 2012Article
- FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice.The Journal of clinical investigation · 2012Article
- Phosphatidylinositol 3'-kinase, mTOR, and glycogen synthase kinase-3β mediated regulation of p21 in human urothelial carcinoma cells.BMC urology · 2011Article
- The CMT4B disease-causing proteins MTMR2 and MTMR13/SBF2 regulate AKT signalling.Journal of cellular and molecular medicine · 2011Article
- The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- Progesterone reverses the mesenchymal phenotypes of basal phenotype breast cancer cells via a membrane progesterone receptor mediated pathway.Breast cancer research : BCR · 2010Article
- Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis.Neuro-oncology · 2005Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We have shown that a type I phosphatidylinositol (PI) kinase activity is associated with the epidermal growth factor (EGF) receptor in a mouse fibroblast cell line expressing human EGF receptors (NRHER5) and that this activity increases dramatically upon treatment of cells with physiologically relevant concentrations of EGF. EGF stimulated a time-dependent increase in EGF receptor-associated PI kinase activity measured in EGF receptor immunoprecipitates. Activation was detected 15 min after the addition of EGF, and it peaked between 1 and 2 hr. Activation of PI kinase was detected with EGF concentrations as low as 10 pM and maximal stimulation occurred at approximately 1 nM. Analysis of deacylated PI phosphate products, and inhibition of the PI kinase activity by nonionic detergent, indicated that the PI kinase described here was type I or PI 3' kinase. These results demonstrate the regulation of a type I PI kinase by EGF and suggest a potential role in the EGF receptor signal transduction pathway.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.