Evidence map›Paper›PMID 21624951›Full record

ArticleThe Journal of cell biology2011

Disturbed flow: p53 SUMOylation in the turnover of endothelial cells.

Wakako Takabe, Noah Alberts-Grill, Hanjoong Jo

Open access · hybridAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. SUMOylation targeting mitophagy in cardiovascular diseases.Journal of molecular medicine (Berlin, Germany) · 2022
    Review
  4. The Role of SUMO E3 Ligases in Signaling Pathway of Cancer Cells.International journal of molecular sciences · 2022
    Review
  5. Review
  6. Review
  7. The regulatory roles of p53 in cardiovascular health and disease.Cellular and molecular life sciences : CMLS · 2021
    Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Wakako TakabeWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30322, USA.
Noah Alberts-Grill
Hanjoong Jo
Emory University · USGeorgia Institute of Technology · USThe Wallace H. Coulter Department of Biomedical Engineering · US

Funding

Biology, Biomechanics and AtherosclerosisR01HL070531 · NHLBI · EMORY UNIVERSITY · PI TAYLOR, WILLIAM ROBERT · 2002 to 2012
$12.7M
Shear and Oxidative Stress Regulate Endothelial Matrix MetalloproteinaseP01HL075209 · NHLBI · EMORY UNIVERSITY · PI GRIENDLING, KATHY K · 2004 to 2008
$7.5M
Shear Stress, BMP and Aortic Valve InflammationR01HL087012 · NHLBI · EMORY UNIVERSITY · PI JO, HANJOONG · 2007 to 2010
$1.9M
NHLBI NIH HHS HHSN268201000043CNHLBI NIH HHS HL75209NHLBI NIH HHS HL87012NHLBI NIH HHS P01 HL075209NHLBI NIH HHS R01 HL070531NHLBI NIH HHS R01 HL087012
6 · The paper itself

Abstract

Disturbed blood flow induces apoptosis of vascular endothelial cells, which causes atherosclerosis. In this issue, Heo et al. (2011. J. Cell Biol. doi:10.1083/jcb.201010051) sheds light on p53's role in this phenomenon. Disturbed flow induces peroxynitrite production, which activates protein kinase C ζ and it's binding to the E3 SUMO (small ubiquitin-like modifier) ligase PIASy (protein inhibitor of activated STATy). This leads to p53 SUMOylation and its export to the cytosol, where it binds to the antiapoptotic protein Bcl-2 to induce apoptosis.

Indexed as

Regional Blood FlowSumoylationApoptosisCytosolEndothelial CellsHumansPeroxynitrous AcidPoly-ADP-Ribose Binding ProteinsProtein Inhibitors of Activated STATProtein Kinase CProtein Kinase C zetaProtein TransportProto-Oncogene Proteins c-bcl-2Tumor Suppressor Protein p53Peroxynitrous AcidPIAS4 protein, humanPoly-ADP-Ribose Binding ProteinsProtein Inhibitors of Activated STATProtein Kinase CProtein Kinase C zetaProto-Oncogene Proteins c-bcl-2Tumor Suppressor Protein p53

Identifiers

PMID21624951
PMCPMC3105545
OpenAlexW2096711368

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.