Evidence map›Paper›PMID 21658712›Full record

ArticleThe Journal of pediatrics2011

Decreased postnatal docosahexaenoic and arachidonic acid blood levels in premature infants are associated with neonatal morbidities.

Camilia R Martin, Deborah A Dasilva, Joanne E Cluette-Brown, Clementina Dimonda, Ashley Hamill, Abdul Q Bhutta, Emmanuel Coronel, Michael Wilschanski, Alisa J Stephens, David F Driscoll and 4 more

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 123 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 3 pooled it
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04069195 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Placebo Controlled Trial of Docosahexaenoic Acid (DHA) Supplementation in High Risk Pregnancies

TypeinterventionalSponsorWalter Reed National Military Medical CenterRan2019 to 2020Enrolled210ConditionsInflammation, Pregnancy RelatedArmsDHA supplement, Corn Oil: Soybean Oil
NCT07652684 phase4recruitingnot on this mapstarted 2025, after this paper: background citation

Enteral Lipid Supplementation and Bronchoplumonary Dysplasia of Premature Infants: A Randomized Controlled Trial (The PRELUDE Trial)

TypeinterventionalSponsorAristotle University Of ThessalonikiRan2025 to 2027Enrolled74ConditionsBronchopulmonary Dysplasia (BPD)ArmsEnteral supplementation with ARA and DHA (in a 2:1 ratio) in addition to standard care and feeding, Standard care and feeding
3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 3 syntheses or guidelines pooled it, 226 citations in OpenAlex.

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63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Camilia R MartinDepartment of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA, USA. cmartin1@bidmc.harvard.edu
Deborah A Dasilva
Joanne E Cluette-Brown
Clementina Dimonda
Ashley Hamill
Abdul Q Bhutta
Emmanuel Coronel
Michael Wilschanski
Alisa J Stephens
David F Driscoll
Bruce R Bistrian
James H Ware
Munir M Zaman
Steven D Freedman
Beth Israel Deaconess Medical Center · USHarvard University · USHadassah Medical Center · IL

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Training Grant in Quantitative Sciences for Cancer ResearchT32CA009337 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI QUACKENBUSH, JOHN, TRIPPA, LORENZO · 1986 to 2025
$12.3M
NCRR NIH HHS UL1 RR 025758NCRR NIH HHS UL1 RR025758
6 · The paper itself

Abstract

objectiveTo measure the changes in whole blood fatty acid levels in premature infants and evaluate associations between these changes and neonatal morbidities. STUDY

designThis was a retrospective cohort study of 88 infants born at <30 weeks' gestation. Serial fatty acid profiles during the first postnatal month and infant outcomes, including chronic lung disease (CLD), retinopathy of prematurity, and late-onset sepsis, were analyzed. Regression modeling was applied to determine the association between fatty acid levels and neonatal morbidities.

resultsDocosahexaenoic acid (DHA) and arachidonic acid levels declined rapidly in the first postnatal week, with a concomitant increase in linoleic acid levels. Decreased DHA level was associated with an increased risk of CLD (OR, 2.5; 95% CI, 1.3-5.0). Decreased arachidonic acid level was associated with an increased risk of late-onset sepsis (hazard ratio, 1.4; 95% CI, 1.1-1.7). The balance of fatty acids was also a predictor of CLD and late-onset sepsis. An increased linoleic acid:DHA ratio was associated with an increased risk of CLD (OR, 8.6; 95% CI, 1.4-53.1) and late-onset sepsis (hazard ratio, 4.6; 95% CI, 1.5-14.1).

conclusionAltered postnatal fatty acid levels in premature infants are associated with an increased risk of CLD and late-onset sepsis.

Indexed as

Arachidonic AcidChronic DiseaseCohort StudiesDocosahexaenoic AcidsFatty AcidsFemaleHumansInfant, NewbornInfant, PrematureLung DiseasesMaleOxygen Inhalation TherapyProportional Hazards ModelsRetinopathy of PrematurityRetrospective StudiesSepsisArachidonic AcidDocosahexaenoic AcidsFatty Acids

Identifiers

PMID21658712
PMCPMC3701520
OpenAlexW2159972202

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.