ArticleJournal of vascular surgery2011
Low lifetime recreational activity is a risk factor for peripheral arterial disease.
Article in Journal of vascular surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- Trial
- The effect of exercise training on ankle-brachial index in type 2 diabetes.Atherosclerosis · 2013Trial
- Arterial stiffness index, physical activity and food and nutrient intake: cross-sectional study in adults aged 40 years and older.Korean journal of community nutrition · 2024Article
- The effects of sedentary behaviour on patients with peripheral arterial Disease: A systematic review.Preventive medicine reports · 2023Review
- Physical activity, cardiorespiratory fitness, and cardiovascular health: A clinical practice statement of the American Society for Preventive Cardiology Part II: Physical activity, cardiorespiratory fitness, minimum and goal intensities for exercise training, prescriptive methods, and special patient populations.American journal of preventive cardiology · 2022Review
- Peripheral arterial disease progression and ankle brachial index: a cohort study with newly diagnosed patients with type 2 diabetes.BMC cardiovascular disorders · 2022Article
- Unsupervised Learning for Automated Detection of Coronary Artery Disease Subgroups.Journal of the American Heart Association · 2021Article
- Midlife Cardiorespiratory Fitness and the Development of Peripheral Artery Disease in Later Life.Journal of the American Heart Association · 2021Article
- Dose-Response Relationship Between Physical Activity and the Incidence of Peripheral Artery Disease in General Population: Insights From the National Health and Nutrition Examination Survey 1999-2004.Frontiers in cardiovascular medicine · 2021Article
- Physical Activity and Subsequent Risk of Hospitalization With Peripheral Artery Disease and Critical Limb Ischemia in the ARIC Study.Journal of the American Heart Association · 2019Article
- Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association.Circulation · 2017Review
- Safety and Effectiveness of Bone Marrow Cell Concentrate in the Treatment of Chronic Critical Limb Ischemia Utilizing a Rapid Point-of-Care System.Stem cells international · 2017Article
- Effect of in-hospital physical activity on cardiovascular prognosis in lower extremity bypass for claudication.Journal of physical therapy science · 2015Article
- A compendium on peripheral arterial disease.Circulation research · 2015Article
- Effect of physical activity assessment on prognostication for peripheral artery disease and mortality.Mayo Clinic proceedings · 2015Article
- The combination of 9p21.3 genotype and biomarker profile improves a peripheral artery disease risk prediction model.Vascular medicine (London, England) · 2014Article
- Heart disease and stroke statistics--2014 update: a report from the American Heart Association.Circulation · 2014Article
- Invasively-treated incidence of lower extremity peripheral arterial disease and associated factors in Taiwan: 2000-2011 nationwide hospitalized data analysis.BMC public health · 2013Article
- Alternative ankle-brachial index method identifies additional at-risk individuals.Journal of the American College of Cardiology · 2013Article
- Walking impairment questionnaire improves mortality risk prediction models in a high-risk cohort independent of peripheral arterial disease status.Circulation. Cardiovascular quality and outcomes · 2013Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe relationship between lifetime physical activity and the risk of developing peripheral arterial disease (PAD) is not known.
methodsWe studied 1381 patients referred for elective coronary angiography in a point prevalence analysis. PAD was defined as ankle-brachial index (ABI) <0.9 at the time or a history of revascularization of the lower extremities regardless of ABI measure. We used a validated physical activity questionnaire to retrospectively measure each patient's lifetime recreational activity (LRA). Multivariate and logistic regression analyses were used to assess the independent association of LRA to ABI and the presence of PAD.
resultsPAD was present in 19% (n = 258) of all subjects. Subjects reporting no regular LRA had greater diastolic blood pressure and were more likely to be female. They had lower average ABI, and a higher proportion had PAD (25.6%). In a regression model, including traditional risk factors and LRA, multivariate analysis showed that age (P < .001), female gender (P < .001), systolic blood pressure (P = .014), fasting glucose (P < .001), serum triglycerides (P = .02), and cumulative pack years (P < .001) were independent negative predictors of ABI, and LRA was a positive predictor of ABI (P < .001). History of sedentary lifestyle independently increased the odds ratio for PAD (odds ratio, 0.46; 95% confidence interval, 1.01-2.10) when assessed by logistic regression. Intriguingly, there is a correlation between physical activity and gender, such that women with low LRA are at greatest risk.
conclusionRecalled LRA is positively correlated to ABI and associated with PAD. Whereas the mechanism for this effect is not clear, LRA may be a useful clinical screening tool for PAD risk, and strategies to increase adult recreational activity may reduce the burden of PAD later in life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.