ArticleBlood2011
GABP transcription factor is required for myeloid differentiation, in part, through its control of Gfi-1 expression.
Article in Blood, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Mitonuclear Communication in Stem Cell Function.Cell proliferation · 2025Review
- Single-cell analyses reveal evolution mimicry during the specification of breast cancer subtype.Theranostics · 2024Article
- Regulatory mechanisms of Robo4 and their effects on angiogenesis.Bioscience reports · 2019Review
- A novel ASXL1-OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies.Leukemia · 2018Article
- Article
- Human Lineage-Specific Transcriptional Regulation through GA-Binding Protein Transcription Factor Alpha (GABPa).Molecular biology and evolution · 2016Article
- Promoter-distal RNA polymerase II binding discriminates active from inactive CCAAT/ enhancer-binding protein beta binding sites.Genome research · 2015Article
- Technical Advance: Transcription factor, promoter, and enhancer utilization in human myeloid cells.Journal of leukocyte biology · 2015Article
- GA binding protein augments autophagy via transcriptional activation of BECN1-PIK3C3 complex genes.Autophagy · 2014Article
- GABP transcription factor (nuclear respiratory factor 2) is required for mitochondrial biogenesis.Molecular and cellular biology · 2014Article
- Biological functional annotation of retinoic acid alpha and beta in mouse liver based on genome-wide binding.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Regulation of monocyte differentiation by specific signaling modules and associated transcription factor networks.Cellular and molecular life sciences : CMLS · 2014Review
- GABP transcription factor is required for development of chronic myelogenous leukemia via its control of PRKD2.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- CD8 lineage-specific regulation of interleukin-7 receptor expression by the transcriptional repressor Gfi1.The Journal of biological chemistry · 2012Article
- Targeting tetramer-forming GABPβ isoforms impairs self-renewal of hematopoietic and leukemic stem cells.Cell stem cell · 2012Article
- Genome-wide DNA methylation profiles in hematopoietic stem and progenitor cells reveal overrepresentation of ETS transcription factor binding sites.Genome research · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
GABP is an ets transcription factor that regulates genes that are required for myeloid differentiation. The tetrameric GABP complex includes GABPα, which binds DNA via its ets domain, and GABPβ, which contains the transcription activation domain. To examine the role of GABP in myeloid differentiation, we generated mice in which Gabpa can be conditionally deleted in hematopoietic tissues. Gabpa knockout mice rapidly lost myeloid cells, and residual myeloid cells were dysplastic and immunophenotypically abnormal. Bone marrow transplantation demonstrated that Gabpα null cells could not contribute to the myeloid compartment because of cell intrinsic defects. Disruption of Gabpa was associated with a marked reduction in myeloid progenitor cells, and Gabpα null myeloid cells express reduced levels of the transcriptional repressor, Gfi-1. Gabp bound and activated the Gfi1 promoter, and transduction of Gabpa knockout bone marrow with Gfi1 partially rescued defects in myeloid colony formation and myeloid differentiation. We conclude that Gabp is required for myeloid differentiation due, in part, to its regulation of the tran-scriptional repressor Gfi-1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.