Trial reportMenopause (New York, N.Y.)2011
Menopause and risk of diabetes in the Diabetes Prevention Program.
Trial report in Menopause (New York, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of cardiometabolic outcomes in women who underwent salpingo-oophorectomy to prevent hereditary breast and ovarian cancer: a meta-analysis.Familial cancer · 2024Pooled it
- Infertility, Gravidity, and Risk Of Diabetes among High-Risk Women in the Diabetes Prevention Program Outcomes Study.The Journal of clinical endocrinology and metabolism · 2020 · on this mapTrial
- Sex-Dependent and Asymmetric Associations of Bodyweight History in the Twenties with Later HbA1c Trajectories in a Japanese Occupational Cohort.Nutrients · 2026Article
- Metformin use in prediabetes: A review of evidence and a focus on metabolic features among peri-menopausal women.Diabetes, obesity & metabolism · 2025Review
- Menopause and Diabetes Risk Along with Trajectory of β-Cell Function and Insulin Sensitivity: A Community-Based Cohort Study.Healthcare (Basel, Switzerland) · 2025Article
- Effect of fasting glucose levels on carotid intima-media thickness in premenopausal versus postmenopausal women.Archives of endocrinology and metabolism · 2024Article
- Changes in insulin resistance, glucose effectiveness, and first and second phases of insulin secretion in women aged 45-60 years old in Taiwan.Journal of the Chinese Medical Association : JCMA · 2023Article
- Menopausal status, age at natural menopause and risk of diabetes in China: a 10-year prospective study of 300,000 women.Nutrition & metabolism · 2022Article
- Body composition and cardiometabolic health across the menopause transition.Obesity (Silver Spring, Md.) · 2022Review
- A prospective study of the relationships between change in body composition and cardiovascular risk factors across the menopause.Menopause (New York, N.Y.) · 2021Article
- Trajectories of Body Weight and Fat Mass in Relation to Incident Prediabetes in a Biracial Cohort of Free-Living Adults.Journal of the Endocrine Society · 2021Article
- Therapeutic potential of genistein in ovariectomy-induced pancreatic injury in diabetic rats: The regulation of MAPK pathway and apoptosis.Iranian journal of basic medical sciences · 2017Article
- The effects of oestrogens and their receptors on cardiometabolic health.Nature reviews. Endocrinology · 2017Review
- Risk of Diabetes After Hysterectomy With or Without Oophorectomy in Postmenopausal Women.American journal of epidemiology · 2017Article
- Sex Hormones and Cardiometabolic Health: Role of Estrogen and Estrogen Receptors.Endocrinology · 2017Review
- Effect of genistein on expression of pancreatic SIRT1, inflammatory cytokines and histological changes in ovariectomized diabetic rat.Iranian journal of basic medical sciences · 2017Article
- Reproductive history and risk of type 2 diabetes mellitus in postmenopausal women: findings from the Women's Health Initiative.Menopause (New York, N.Y.) · 2017Article
- Hormone replacement therapy in young women with surgical primary ovarian insufficiency.Fertility and sterility · 2016Review
- Diabetes and Menopause.Current diabetes reports · 2016Review
- Factors associated with the age of the onset of diabetes in women aged 50 years or more: a population-based study.BMJ open · 2014Article
Corrections and comments
- Commented on by
Authors and funding
11 authors.
Funding
Abstract
objectiveThe study objectives were to examine the association between menopause status and diabetes risk among women with glucose intolerance and to determine if menopause status modifies response to diabetes prevention interventions.
methodsThe study population included women in premenopause (n = 708), women in natural postmenopause (n = 328), and women with bilateral oophorectomy (n = 201) in the Diabetes Prevention Program, a randomized placebo-controlled trial of lifestyle intervention and metformin among glucose-intolerant adults. Associations between menopause and diabetes risk were evaluated using Cox proportional hazard models that adjusted for demographic variables (age, race/ethnicity, family history of diabetes, history of gestational diabetes mellitus), waist circumference, insulin resistance, and corrected insulin response. Similar models were constructed after stratification by menopause type and hormone therapy use.
resultsAfter adjustment for age, there was no association between natural menopause or bilateral oophorectomy and diabetes risk. Differences by study arm were observed in women who reported bilateral oophorectomy. In the lifestyle arm, women with bilateral oophorectomy had a lower adjusted hazard for diabetes (hazard ratio [HR], 0.19; 95% CI, 0.04-0.94), although observations were too few to determine if this was independent of hormone therapy use. No significant differences were seen in the metformin (HR, 1.29; 95% CI, 0.63-2.64) or placebo arms (HR, 1.37; 95% CI, 0.74-2.55).
conclusionsAmong women at high risk for diabetes, natural menopause was not associated with diabetes risk and did not affect response to diabetes prevention interventions. In the lifestyle intervention, bilateral oophorectomy was associated with a decreased diabetes risk.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.