Evidence mapPaperPMID 21712404Full record

GuidelineEuropean heart journal2011

ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS).

European Association for Cardiovascular Prevention & Rehabilitation, Zeljko Reiner, Alberico L Catapano, Guy De Backer, Ian Graham, Marja-Riitta Taskinen, Olov Wiklund, Stefan Agewall, Eduardo Alegria, M John Chapman and 10 more

5 registry-linked trialsAbstract readPractice Guideline
PubMed Publisher
In one paragraph

Guideline in European heart journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 896 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
896citing papers in PubMed, 12 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03329729 completedstarted 2018, after this paper: background citation

Non-interventional, Multicenter Clinical Trial to Investigate the Efficacy of Rosuvastatin in Patients With Hyperlipidemia and Other Cardiovascular Risk Factors.

Ran2018Enrolled4,700Registered outcomes3Posted comparisons0ConditionsDyslipidemias, Hyperlipidemias, Quality of Life, Risk Factor, CardiovascularArmsRosuvastatin
Open the trial in the graph
NCT04826354 phase4completedstarted 2021, after this paper: background citation

Effects of High-dose StAtin Versus Low-dose Statin Plus Ezetimibe on Statin-Associated Muscle Symptoms & on Reaching Target LDL-C Levels Among Elderly Patients With Atherosclerotic Cardiovascular Disease

Ran2021Enrolled582Registered outcomes11Posted comparisons0ConditionsAtheroscleroses, CoronaryArmsRosuvastatin, rosuvastatin and ezetimibe
Open the trial in the graph
NCT02314663 naunknown statusnot on this mapstarted 2013, after this paper: background citation

Effectiveness of a Combined Strategy to Improve Therapeutic Compliance and Degree of Control Among Patients With Hypercholesterolaemia: a Randomised Clinical Trial

TypeinterventionalSponsorGerencia de Atención Primaria, AlbaceteRan2013 to 2015Enrolled358ConditionsHypercholesterolemia, Medication Adherence, Primary Health CareArms"COMBINED STRATEGY"
NCT02453919 recruitingnot on this map

Register of Cardiovascular Complications Among People Living With HIV

Typeobservational_patient_registrySponsorSaint Antoine University HospitalRan2010 to 2030Enrolled800ConditionsHIV, Cardiovascular Diseases
NCT02597127 phase2completednot on this mapstarted 2016, after this paper: background citation

A Placebo-controlled, Double-blind, Randomized Trial to Compare the Effect of Different Doses of ALN-PCSSC Given as Single or Multiple Subcutaneous Injections in Subjects With High Cardiovascular Risk and Elevated LDL-C

TypeinterventionalSponsorThe Medicines CompanyRan2016 to 2017Enrolled501ConditionsAtherosclerotic Cardiovascular Disease, Familial Hypercholesterolemia, DiabetesArmsALN-PCSSC, Normal Saline
3 · Its place in the literature

Who cites it

896 citing papers in PubMed, 12 syntheses or guidelines pooled it.

  1. Pooled it
  2. The Role ofNutrients · 2025
    Pooled it
  3. Pooled it
  4. Familial hypercholesterolemia - treatment update in children, systematic review.Pediatric endocrinology, diabetes, and metabolism · 2022
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Frontiers in pharmacology · 2022
    Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Observational
  18. Article
  19. Review
  20. Observational

836 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

European Association for Cardiovascular Prevention & RehabilitationUniversity Hospital Center Zagreb, School of Medicine, University of Zagreb, Salata 2, 10 000 Zagreb, Croatia. zreiner@kbc-zagreb.hr
Zeljko Reiner
Alberico L Catapano
Guy De Backer
Ian Graham
Marja-Riitta Taskinen
Olov Wiklund
Stefan Agewall
Eduardo Alegria
M John Chapman
Paul Durrington
Serap Erdine
Julian Halcox
Richard Hobbs
John Kjekshus
Pasquale Perrone Filardi
Gabriele Riccardi
Robert F Storey
David Wood
ESC Committee for Practice Guidelines (CPG) 2008-2010 and 2010-2012 Committees

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular disease (CVD) due to atherosclerosis of the arterial vessel wall and to thrombosis is the foremost cause of premature mortality and of disability-adjusted life years (DALYs) in Europe, and is also increasingly common in developing countries.1 In the European Union, the economic cost of CVD represents annually E192 billion1 in direct and indirect healthcare costs. The main clinical entities are coronary artery disease (CAD), ischaemic stroke, and peripheral arterial disease (PAD). The causes of these CVDs are multifactorial. Some of these factors relate to lifestyles, such as tobacco smoking, lack of physical activity, and dietary habits, and are thus modifiable. Other risk factors are also modifiable, such as elevated blood pressure, type 2 diabetes, and dyslipidaemias, or non-modifiable, such as age and male gender. These guidelines deal with the management of dyslipidaemias as an essential and integral part of CVD prevention. Prevention and treatment of dyslipidaemias should always be considered within the broader framework of CVD prevention, which is addressed in guidelines of the Joint European Societies’ Task forces on CVD prevention in clinical practice.2 – 5 The latest version of these guidelines was published in 20075; an update will become available in 2012. These Joint ESC/European Atherosclerosis Society (EAS) guidelines on the management of dyslipidaemias are complementary to the guidelines on CVD prevention in clinical practice and address not only physicians [e.g. general practitioners (GPs) and cardiologists] interested in CVD prevention, but also specialists from lipid clinics or metabolic units who are dealing with dyslipidaemias that are more difficult to classify and treat.

Indexed as

AdultCardiovascular DiseasesChildDietDietary FatsDietary SupplementsDyslipidemiasEarly DiagnosisEnergy IntakeExerciseFemaleHumansHypolipidemic AgentsKidney Failure, ChronicLife StyleLipid MetabolismDietary FatsHypolipidemic Agents

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.