Trial reportClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2011
Effect of inhaled dust mite allergen on regional particle deposition and mucociliary clearance in allergic asthmatics.
Trial report in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00448851 (Phase 1 Study of Dermatophagoides Farinae Inhalation in Humans), which is not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase 1 Study of Dermatophagoides Farinae Inhalation in Humans
Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Short course gamma tocopherol did not mitigate effects of ozone on airway inflammation in asthmatics.Inhalation toxicology · 2020Trial
- Gamma tocopherol-enriched supplement reduces sputum eosinophilia and endotoxin-induced sputum neutrophilia in volunteers with asthma.The Journal of allergy and clinical immunology · 2018Trial
- Patients with asthma demonstrate airway inflammation after exposure to concentrated ambient particulate matter.American journal of respiratory and critical care medicine · 2014Trial
- Oral losartan yields subtherapeutic airway exposure compared to nebulized delivery and fails to improve mucociliary clearance in cystic fibrosis.Frontiers in pharmacology · 2026Article
- Associations of exposure to PMThe Science of the total environment · 2024Article
- Airway IL-1β associates with IL-5 production following dust mite allergen inhalation in humans.Respiratory research · 2021Article
- Acute and durable effect of inhaled hypertonic saline on mucociliary clearance in adult asthma.ERJ open research · 2021Article
- Indoor Air Quality Levels in Schools: Role of Student Activities and No Activities.International journal of environmental research and public health · 2020Article
- Article
- Fifteen Years of Airborne ParticulatesInternational journal of molecular sciences · 2020Review
- The Role of Dust Mites in Allergy.Clinical reviews in allergy & immunology · 2019Review
- Health Services Utilization in Asthma Exacerbations and PMAnnals of the American Thoracic Society · 2018Article
- Regional Ventilation Is the Main Determinant of Alveolar Deposition of Coarse Particles in the Supine Healthy Human Lung During Tidal Breathing.Journal of aerosol medicine and pulmonary drug delivery · 2017Article
- Atopic asthmatic immune phenotypes associated with airway microbiota and airway obstruction.PloS one · 2017Article
- Duration of action of hypertonic saline on mucociliary clearance in the normal lung.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Heterogeneity of Particle Deposition by Pixel Analysis of 2D Gamma Scintigraphy Images.Journal of aerosol medicine and pulmonary drug delivery · 2015Article
- Aerosol deposition in the human lung in reduced gravity.Journal of aerosol medicine and pulmonary drug delivery · 2014Review
- Environmental assessment and exposure control of dust mites: a practice parameter.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2013Article
- Regional distribution of aerosol deposition in rat lungs using magnetic resonance imaging.Annals of biomedical engineering · 2013Article
- Effect of inhaled endotoxin on regional particle deposition in patients with mild asthma.The Journal of allergy and clinical immunology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAcute exacerbations in allergic asthmatics may lead to impaired ability to clear mucus from the airways, a key factor in asthma morbidity.
objectiveThe purpose of this study was to determine the effect of inhaled house dust mite challenge on the regional deposition of inhaled particles and mucociliary clearance (MCC) in allergic asthmatics.
methodsWe used gamma scintigraphy (inhalation of (99m) Tc -sulphur colloid particles) to measure the regional particle deposition and MCC in allergic asthmatics (n=12) 4 h following an inhaled dust mite allergen challenge (Dermatophagoides farinae extract; PD(max) =fall in forced expiratory volume in 1 s of 10%) for comparison with baseline non-challenge measures.
resultsIn responders (n=9 PD(max) dose), lung function returned to pre-challenge values by 3 h but was significantly decreased at 6 and 24 h in three of the responders (i.e. late-phase response) and induced sputum eosinophils were increased at 24 h post-challenge (P<0.05). Responders showed enhanced bronchial airway deposition of inhaled particles (P<0.05) and slowed clearance from the central lung zone (P<0.01) at 4 h post-challenge compared with the baseline (no allergen challenge) that was predicted by the PD(max) allergen concentration (r=-0.70, P<0.05). The decline in lung function at 24 h post-challenge correlated with reduced MCC from the central lung zone (r=-0.78, P<0.02) and PD(max) . Non-responders (n=3) showed no change in lung function, regional deposition or MCC post-challenge vs. baseline. CONCLUSIONS AND CLINICAL RELEVANCE: These data suggest that regional deposition and clearance of inhaled particles may be sensitive for detecting mild airway obstruction associated with early- and late-phase allergen-induced effects on mucus secretions. The study was listed on clinicaltrials.gov (NCT00448851).
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.