Evidence mapPaperPMID 21743048Full record

ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2011

Integrating health into cognitive aging: toward a preventive cognitive neuroscience of aging.

Avron Spiro, Christopher B Brady

Abstract read
In one paragraph

Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
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  5. Electrophysiological signatures of brain aging in autism spectrum disorder.Cortex; a journal devoted to the study of the nervous system and behavior · 2022
    Article
  6. Article
  7. Article
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  9. Article
  10. Memory Deficits Precede Increases in Depressive Symptoms in Later Adulthood.The journals of gerontology. Series B, Psychological sciences and social sciences · 2019
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Cognitive Aging in Parents of Children with Disabilities.The journals of gerontology. Series B, Psychological sciences and social sciences · 2016
    Article
  16. Article
  17. Article
  18. Association of vascular risk factors with cognition in a multiethnic sample.The journals of gerontology. Series B, Psychological sciences and social sciences · 2015
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Avron SpiroMassachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Massachusetts, USA. aspiro3@bu.edu
Christopher B Brady

Funding

PERSONALITY AND WELL BEING TRAJECTORIES IN ADULTHOODR01AG018436 · NIA · PURDUE UNIVERSITY WEST LAFAYETTE · PI MROCZEK, DANIEL K. · 2000 to 2020
$6.7M
LANGUAGE IN THE AGING BRAINR01AG014345 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ALBERT, MARTIN L, OBLER, LORAINE K. · 1997 to 2015
$5.4M
Integrative Analysis of Change in Cognition and HealthR01AG026453 · NIA · UNIVERSITY OF VICTORIA · PI HOFER, SCOTT M. · 2007 to 2011
$2.0M
NIA NIH HHS 01-AG014345NIA NIH HHS R01 AG014345NIA NIH HHS R01-AG018436NIA NIH HHS R01 AG026453
6 · The paper itself

Abstract

objectivesWe argue that age is a descriptive, and not explanatory, variable and consequently cannot account for the cognitive changes that often occur with aging. Once age is removed from consideration, other truly causal explanations for "cognitive aging" must be identified. We argue that health and disease represent an important class of explanatory variables for age-related cognitive changes. METHODS/

resultsWe make this argument first by reviewing the prevalence of risk factors, disability, and subclinical and frank disease in the elderly population. We emphasize that the complexity of health effects rivals that of age on cognition while noting that most studies of cognitive aging rarely consider this complexity fully. We then consider in more detail the "vascular hypothesis," which proposes that vascular diseases (e.g., stroke, heart disease) and their risk factors (e.g., hypertension) can explain aspects of cognitive decline in aging through their impact on circulatory and brain functions. Clinical implications of this hypothesis suggest that treatment of vascular risk factors might well reduce the incidence or severity of dementia syndromes. DISCUSSION: We conclude with a brief summary of approaches to further integrate aspects of health and disease into the study of "cognitive aging."

Indexed as

AgedAge FactorsAgingBrainCardiovascular SystemCognitionCognition DisordersFemaleHealth StatusHumansMaleModels, BiologicalPrevalenceRisk FactorsSex Factors

Identifiers

PMID21743048
PMCPMC3132768

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.