ArticleNucleic acids research2011
Local sensing of global DNA topology: from crossover geometry to type II topoisomerase processivity.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
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- Towards the Idea of Molecular Brains.International journal of molecular sciences · 2021Review
- DNA-Topology Simplification by Topoisomerases.Molecules (Basel, Switzerland) · 2021Review
- Structural and functional characterization of the Spo11 core complex.Nature structural & molecular biology · 2021Article
- Topoisomerase IIβ targets DNA crossovers formed between distant homologous sites to induce chromatin opening.Scientific reports · 2020Article
- Effect of static magnetic field on DNA synthesis: The interplay between DNA chirality and magnetic field left-right asymmetry.FASEB bioAdvances · 2020Article
- Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.Nature communications · 2018Article
- Activities of gyrase and topoisomerase IV on positively supercoiled DNA.Nucleic acids research · 2017Article
- Direct Evidence for the Formation of Precatenanes during DNA Replication.The Journal of biological chemistry · 2015Article
- DNA Topoisomerases.EcoSal Plus · 2015Review
- Characteristics of replication-independent endogenous double-strand breaks in Saccharomyces cerevisiae.BMC genomics · 2014Article
- Structural insight into negative DNA supercoiling by DNA gyrase, a bacterial type 2A DNA topoisomerase.Nucleic acids research · 2013Article
- Chiral discrimination and writhe-dependent relaxation mechanism of human topoisomerase IIα.The Journal of biological chemistry · 2013Article
- DNA self-assembly: from chirality to evolution.International journal of molecular sciences · 2013Review
- Comparison of DNA decatenation by Escherichia coli topoisomerase IV and topoisomerase III: implications for non-equilibrium topology simplification.Nucleic acids research · 2013Article
- DNA-directed base pair opening.Molecules (Basel, Switzerland) · 2012Review
- Topo IV is the topoisomerase that knots and unknots sister duplexes during DNA replication.Nucleic acids research · 2012Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type II topoisomerases are ubiquitous enzymes that control the topology and higher order structures of DNA. Type IIA enzymes have the remarkable property to sense locally the global DNA topology. Although many theoretical models have been proposed, the molecular mechanism of chiral discrimination is still unclear. While experimental studies have established that topoisomerases IIA discriminate topology on the basis of crossover geometry, a recent single-molecule experiment has shown that the enzyme has a different processivity on supercoiled DNA of opposite sign. Understanding how cross-over geometry influences enzyme processivity is, therefore, the key to elucidate the mechanism of chiral discrimination. Analysing this question from the DNA side reveals first, that the different stability of chiral DNA cross-overs provides a way to locally sense the global DNA topology. Second, it shows that these enzymes have evolved to recognize the G- and T-segments stably assembled into a right-handed cross-over. Third, it demonstrates how binding right-handed cross-overs across their large angle imposes a different topological link between the topoIIA rings and the plectonemes of opposite sign thus directly affecting the enzyme freedom of motion and processivity. In bridging geometry and kinetic data, this study brings a simple solution for type IIA topoisomerase chiral discrimination.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.