ArticleBiophysical journal2011
C-terminus of apolipoprotein A-I removes phospholipids from a triolein/phospholipids/water interface, but the N-terminus does not: a possible mechanism for nascent HDL assembly.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Computational Studies of Lipid Droplets.The journal of physical chemistry. B · 2022Review
- Structure and intermolecular interactions in spheroidal high-density lipoprotein subpopulations.Journal of structural biology: X · 2021Article
- Dual binding motifs underpin the hierarchical association of perilipins1-3 with lipid droplets.Molecular biology of the cell · 2019Article
- Aromatic residues in the C terminus of apolipoprotein C-III mediate lipid binding and LPL inhibition.Journal of lipid research · 2017Article
- Interdigitation between Triglycerides and Lipids Modulates Surface Properties of Lipid Droplets.Biophysical journal · 2017Article
- A Pressure-dependent Model for the Regulation of Lipoprotein Lipase by Apolipoprotein C-II.The Journal of biological chemistry · 2015Article
- Surface tensiometry of apolipoprotein B domains at lipid interfaces suggests a new model for the initial steps in triglyceride-rich lipoprotein assembly.The Journal of biological chemistry · 2014Article
- Surface behavior of apolipoprotein A-I and its deletion mutants at model lipoprotein interfaces.Journal of lipid research · 2014Article
- The biophysics and cell biology of lipid droplets.Nature reviews. Molecular cell biology · 2013Review
- Changes in helical content or net charge of apolipoprotein C-I alter its affinity for lipid/water interfaces.Journal of lipid research · 2013Article
- Surface pressure-dependent conformation change of apolipoprotein-derived amphipathic α-helices.Journal of lipid research · 2013Article
- Interfacial properties of high-density lipoprotein-like lipid droplets with different lipid and apolipoprotein A-I compositions.Biophysical journal · 2013Article
- Interfacial tension and surface pressure of high density lipoprotein, low density lipoprotein, and related lipid droplets.Biophysical journal · 2012Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Apolipoprotein A-I (ApoA-I) is the principle protein component of HDL, also known as "good cholesterol," which is an inverse marker for cardiovascular disease. The N-terminal 44 amino acids of ApoA-I (N44) are predicted to be responsible for stabilization of soluble ApoA-I, whereas the C-terminal 46 amino acids (C46) are predicted to initiate lipid binding and oligomerization. In this work, we apply what we believe to be a novel application of drop tensiometry to study the adsorption and desorption of N44 and C46 at a triolein/POPC/water (TO/POPC/W) interface. The amount of peptide that adsorbed to the surface was dependent on the surface concentration of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and pressure (Π) before adsorption. At a TO/POPC/W interface, the exclusion pressure (Π(EX)) of C46 was 25.8 mN/m, and was 19.3 mN/m for N44. Once adsorbed, both peptides formed a homogeneous surface with POPC but were progressively ejected from the surface by compression. During a compression, C46 removed POPC from the surface whereas N44 did not. Repeated compressions caused C46 to deplete entirely the surface of phospholipid. If full-length ApoA-I could also remove phospholipid, this could provide a mechanism for the transfer of surface components of chylomicrons and very low density lipoprotein to high density lipoprotein with the assistance of phospholipid transfer protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.