ArticleJournal of magnetic resonance imaging : JMRI2011
MR properties of brown and white adipose tissues.
Article in Journal of magnetic resonance imaging : JMRI, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01517581 (Study on the Association Between Brown Adipose Tissue Activation and White Adipose Tissue Accumulation in Successfully Treated Pediatric Malignancy), which is not on this map. Cited by 67 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study on the Association Between Brown Adipose Tissue Activation and White Adipose Tissue Accumulation in Successfully Treated Pediatric Malignancy
Who cites it
67 citing papers in PubMed, 120 citations in OpenAlex.
- The Effects of Nitrate on Brown Fat Fraction and Activation in Older Adults With Type 2 Diabetes: A Randomised, Double-Blind and Placebo-Controlled Crossover Trial.European journal of sport science · 2026Trial
- Evaluation of high-fat diet-induced metabolic impairments in iBAT lipid metabolism usingMagma (New York, N.Y.) · 2026Article
- Patient-Specific Biases in Fat Fraction Estimates of Malignant Bone Marrow due to Relaxation Times Measured With STEAM at 3T.NMR in biomedicine · 2026Article
- Motion-robust proton density fat fraction andMagma (New York, N.Y.) · 2026Article
- MR-based fat fraction changes in subcutaneous adipose tissue in people with obesity undergoing a weight loss intervention: results from the LION study.Quantitative imaging in medicine and surgery · 2025Article
- Irisin reverses high-fat diet-induced metabolic dysfunction via activation of brown adipose tissue in mice.International journal of obesity (2005) · 2025Article
- Non-invasive mapping of brown adipose tissue activity with magnetic resonance imaging.Nature metabolism · 2024Article
- Article
- Tracers and Imaging of Fatty Acid and Energy Metabolism of Human Adipose Tissues.Physiology (Bethesda, Md.) · 2024Review
- The epicardial adipose tissue confined in the atrioventricular groove can be used to assess atrial adipose tissue and atrial dysfunction in cardiac magnetic resonance imaging.European heart journal. Imaging methods and practice · 2024Article
- MRI Methods to Visualize and Quantify Adipose Tissue in Health and Disease.Biomedicines · 2023Review
- Feasibility of joint mapping of triglyceride saturation and water longitudinal relaxation in a single breath hold applied to high fat-fraction adipose depots in the periclavicular anatomy.Magnetic resonance imaging · 2023Article
- Brown Adipose Tissue-A Translational Perspective.Endocrine reviews · 2023Review
- High-fructose feeding suppresses cold-stimulated brown adipose tissue glucose uptake independently of changes in thermogenesis and the gut microbiome.Cell reports. Medicine · 2022Article
- Myocardial T1, T2, T2*, and fat fraction quantification via low-rank motion-corrected cardiac MR fingerprinting.Magnetic resonance in medicine · 2022Article
- Brown adipose tissue fat-fraction is associated with skeletal muscle adiposity.European journal of applied physiology · 2022Article
- Quantification of brown adipose tissueQuantitative imaging in medicine and surgery · 2022Article
- Noninvasive, longitudinal imaging-based analysis of body adipose tissue and water composition in a melanoma mouse model and in immune checkpoint inhibitor-treated metastatic melanoma patients.Cancer immunology, immunotherapy : CII · 2021Article
- Proton MR Spectroscopy Measurements of White and Brown Adipose Tissue in Healthy Humans: Relaxation Parameters and Unsaturated Fatty Acids.Radiology · 2021Article
- Feasibility of Hepatic Fat Quantification Using Proton Density Fat Fraction by Multi-Echo Chemical-Shift-Encoded MRI at 7T.Frontiers in physics · 2021Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo explore the MR signatures of brown adipose tissue (BAT) compared with white adipose tissue (WAT) using single-voxel MR spectroscopy. MATERIALS AND
methods(1) H MR STEAM spectra were acquired from a 3 Tesla clinical whole body scanner from seven excised murine adipose tissue samples of BAT (n=4) and WAT (n=3). Spectra were acquired at multiple echo times (TEs) and inversion times (TIs) to measure the T1, T2, and T2-corrected peak areas. A theoretical triglyceride model characterized the fat in terms of number of double bonds (ndb) and number of methylene-interrupted double bonds (nmidb).
resultsNegligible differences between WAT and BAT were seen in the T1 and T2 of fat and the T2 of water. However, the water fraction in BAT was higher (48.5%) compared with WAT (7.1%) and the T1 of water was lower in BAT (618 ms) compared with WAT (1053 ms). The fat spectrum also differed, indicating lower levels of unsaturated triglycerides in BAT (ndb=2.7, nmidb=0.7) compared with WAT (ndb=3.3, nmidb=1.0).
conclusionWe have demonstrated that there are several key MR-based signatures of BAT and WAT that may allow differentiation on MR imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.