ArticleInternational journal of nephrology2011
The Relation between Fructose-Induced Metabolic Syndrome and Altered Renal Haemodynamic and Excretory Function in the Rat.
Article in International journal of nephrology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Fructose consumption and metabolic hypertension in rats: a systematic review and meta-analysis.PeerJ · 2025Pooled it
- Comparison of TyG indices and atherogenic index of plasma with hypertension in the PERSIAN Guilan cohort.Scientific reports · 2026Article
- Activation of AMPD2 drives metabolic dysregulation and liver disease in mice with hereditary fructose intolerance.Communications biology · 2024Article
- Sex modifies the renal consequences of high fructose consumption introduced after weaning.Frontiers in physiology · 2023Article
- Maternal Fructose Intake, Programmed Mitochondrial Function and Predisposition to Adult Disease.International journal of molecular sciences · 2022Review
- Maternal fructose intake during pregnancy and lactation: Later effects on renal function.Physiological reports · 2022Article
- The Role of Selenoprotein Tissue Homeostasis in MetS Programming: Energy Balance and Cardiometabolic Implications.Antioxidants (Basel, Switzerland) · 2022Review
- Article
- Effects of maternal fructose intake on the offspring's kidneys.Frontiers in physiology · 2022Article
- Telmisartan detection by UV spectrophotometry in mice drinking water.Analytical science advances · 2021Article
- The Speed of Ingestion of a Sugary Beverage Has an Effect on the Acute Metabolic Response to Fructose.Nutrients · 2021Article
- Methanol (80%) leaf extract of Otostegia integrifolia Benth (Lamiaceae) lowers blood pressure in rats through interference with calcium conductance.BMC complementary medicine and therapies · 2021Article
- Fructose Consumption During Pregnancy Influences Milk Lipid Composition and Offspring Lipid Profiles in Guinea Pigs.Frontiers in endocrinology · 2020Article
- The role of the baroreflex and parasympathetic nervous system in fructose-induced cardiac and metabolic alterations.Scientific reports · 2018Article
- Moderate (20%) fructose-enriched diet stimulates salt-sensitive hypertension with increased salt retention and decreased renal nitric oxide.Physiological reports · 2017Article
- Metabolic syndrome and selenium during gestation and lactation.European journal of nutrition · 2017Article
- Article
- Regulatory landscape of AGE-RAGE-oxidative stress axis and its modulation by PPARγ activation in high fructose diet-induced metabolic syndrome.Nutrition & metabolism · 2017Article
- Saffron with resistance exercise improves diabetic parameters through the GLUT4/AMPK pathway in-vitro and in-vivo.Scientific reports · 2016Article
- Metabolic syndrome and the hepatorenal reflex.Surgical neurology international · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper explores the possible relationships between dietary fructose and altered neurohumoral regulation of renal haemodynamic and excretory function in this model of metabolic syndrome. Fructose consumption induces hyperinsulinemia, hypertriglyceridaemia, insulin resistance, and hypertension. The pathogenesis of fructose-induced hypertension is dubious and involves numerous pathways acting both singly and together. In addition, hyperinsulinemia and hypertension contribute significantly to progressive renal disease in fructose-fed rats. Moreover, increased activity of the renin-angiotensin and sympathetic nervous systems leading to downregulation of receptors may be responsible for the blunted vascular sensitivity to angiotensin II and catecholamines, respectively. Various approaches have been suggested to prevent the development of fructose-induced hypertension and/or metabolic alteration. In this paper, we address the role played by the renin-angiotensin and sympathetic nervous systems in the haemodynamic alterations that occur due to prolonged consumption of fructose.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.