ArticleBMC medical genetics2011
A follow-up study for left ventricular mass on chromosome 12p11 identifies potential candidate genes.
Article in BMC medical genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Interactions between genetic and lifestyle factors on cardiometabolic disease-related outcomes in Latin American and Caribbean populations: A systematic review.Frontiers in nutrition · 2023Pooled it
- Genome-wide meta-analysis of SNP and antihypertensive medication interactions on left ventricular traits in African Americans.Molecular genetics & genomic medicine · 2019Pooled it
- Aging reveals a sex-dependent susceptibility of sarcospan-deficient mice to cardiometabolic disease.American journal of physiology. Heart and circulatory physiology · 2024Article
- Article
- Conserved sequence motifs in human TMTC1, TMTC2, TMTC3, and TMTC4, new O-mannosyltransferases from the GT-C/PMT clan, are rationalized as ligand binding sites.Biology direct · 2021Article
- Genetic Contributors of Incident Stroke in 10,700 African Americans With Hypertension: A Meta-Analysis From the Genetics of Hypertension Associated Treatments and Reasons for Geographic and Racial Differences in Stroke Studies.Frontiers in genetics · 2021Article
- High expression levels and localization of Sox5 in dilated cardiomyopathy.Molecular medicine reports · 2020Article
- Endoplasmic reticulum transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin, cellular adherence, and embryonic gastrulation.Molecular biology of the cell · 2020Article
- Genome-wide association study of morbid obesity in Han Chinese.BMC genetics · 2019Article
- A genome-wide association study for harness racing success in the Norwegian-Swedish coldblooded trotter reveals genes for learning and energy metabolism.BMC genetics · 2018Article
- Genetically determined pattern of left ventricular function in normal and hypertensive hearts.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Sequencing of Linkage Region on Chromosome 12p11 IdentifiesG3 (Bethesda, Md.) · 2018Article
- Silencing of the Drosophila ortholog of SOX5 leads to abnormal neuronal development and behavioral impairment.Human molecular genetics · 2017Article
- Medical genetics and genomic medicine in the Dominican Republic: challenges and opportunities.Molecular genetics & genomic medicine · 2016Article
- Detection of genome-wide copy number variations in two chicken lines divergently selected for abdominal fat content.BMC genomics · 2014Article
- Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography.Human molecular genetics · 2013Article
- A multi-platform draft de novo genome assembly and comparative analysis for the Scarlet Macaw (Ara macao).PloS one · 2013Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundLeft ventricular mass (LVM) is an important risk factor for cardiovascular disease. Previously we found evidence for linkage to chromosome 12p11 in Dominican families, with a significant increase in a subset of families with high average waist circumference (WC). In the present study, we use association analysis to further study the genetic effect on LVM.
methodsAssociation analysis with LVM was done in the one LOD critical region of the linkage peak in an independent sample of 897 Caribbean Hispanics. Genotype data were available on 7085 SNPs from 23 to 53 MB on chromosome 12p11. Adjustment was made for vascular risk factors and population substructure using an additive genetic model. Subset analysis by WC was performed to test for a difference in genetic effects between the high and low WC subsets.
resultsIn the overall analysis, the most significant association was found to rs10743465, downstream of the SOX5 gene (p = 1.27E-05). Also, 19 additional SNPs had nominal p < 0.001. In the subset analysis, the most significant difference in genetic effect between those with high and low WC occurred with rs1157480 (p = 1.37E-04 for the difference in β coefficients), located upstream of TMTC1. Twelve additional SNPs in or near 6 genes had p < 0.001.
conclusionsThe current study supports previously identified evidence by linkage for a genetic effect on LVM on chromosome 12p11 using association analysis in population-based Caribbean Hispanic cohort. SOX5 may play an important role in the regulation of LVM. An interaction of TMTC1 with abdominal obesity may contribute to phenotypic variation of LVM.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.