ArticleHuman genetics2012
Analysis of family- and population-based samples in cohort genome-wide association studies.
Article in Human genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- APOM and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema.The European respiratory journal · 2014Pooled it
- Integrating SNP data to reveal the adaptive selection features of goat populations in extreme environments.BMC genomics · 2025Article
- The impact of disregarding family structure on genome-wide association analysis of complex diseases in cohorts with simple pedigrees.Journal of applied genetics · 2020Article
- Polygenic risk score for disability and insights into disability-related molecular mechanisms.GeroScience · 2019Article
- Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2017Article
- Genome-wide association study of copy number variation with lung function identifies a novel signal of association near BANP for forced vital capacity.BMC genetics · 2016Article
- Childhood-Onset Essential Hypertension and the Family Structure.Journal of clinical hypertension (Greenwich, Conn.) · 2016Observational
- Efficient generalized least squares method for mixed population and family-based samples in genome-wide association studies.Genetic epidemiology · 2014Article
- LEVERAGING LOCAL IDENTITY-BY-DESCENT INCREASES THE POWER OF CASE/CONTROL GWAS WITH RELATED INDIVIDUALS.The annals of applied statistics · 2014Article
- Integrating prospective longitudinal data: modeling personality and health in the Terman Life Cycle and Hawaii Longitudinal Studies.Developmental psychology · 2014Article
- Gene-gene interactions in APOL1-associated nephropathy.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2014Article
- JC polyoma virus interacts with APOL1 in African Americans with nondiabetic nephropathy.Kidney international · 2013Article
- How the quality of GWAS of human lifespan and health span can be improved.Frontiers in genetics · 2013Article
- Cigarette smoking and airway wall thickness on CT scan in a multi-ethnic cohort: the MESA Lung Study.Respiratory medicine · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Cohort studies typically sample unrelated individuals from a population, although family members of index cases may also be recruited to investigate shared familial risk factors. Recruitment of family members may be incomplete or ancillary to the main cohort, resulting in a mixed sample of independent family units, including unrelated singletons and multiplex families. Multiple methods are available to perform genome-wide association (GWA) analysis of binary or continuous traits in families, but it is unclear whether methods known to perform well on ascertained pedigrees, sibships, or trios are appropriate in analysis of a mixed unrelated cohort and family sample. We present simulation studies based on Multi-Ethnic Study of Atherosclerosis (MESA) pedigree structures to compare the performance of several popular methods of GWA analysis for both quantitative and dichotomous traits in cohort studies. We evaluate approaches suitable for analysis of families, and combined the best performing methods with population-based samples either by meta-analysis, or by pooled analysis of family- and population-based samples (mega-analysis), comparing type 1 error and power. We further assess practical considerations, such as availability of software and ability to incorporate covariates in statistical modeling, and demonstrate our recommended approaches through quantitative and binary trait analysis of HDL cholesterol (HDL-C) in 2,553 MESA family- and population-based African-American samples. Our results suggest linear modeling approaches that accommodate family-induced phenotypic correlation (e.g., variance-component model for quantitative traits or generalized estimating equations for dichotomous traits) perform best in the context of combined family- and population-based cohort GWAS.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.