ArticleBiochimica et biophysica acta2012
A systems genetic analysis of high density lipoprotein metabolism and network preservation across mouse models.
Article in Biochimica et biophysica acta, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Mining cholesterol genes from thousands of mouse livers identifies aldolase C as a regulator of cholesterol biosynthesis.Journal of lipid research · 2024Article
- Gene network based analysis identifies a coexpression module involved in regulating plasma lipids with high-fat diet response.The Journal of nutritional biochemistry · 2023Article
- Integrative Analyses RevealCells · 2021Article
- Gene Expression Differences Between Young Adults Based on Trauma History and Post-traumatic Stress Disorder.Frontiers in psychiatry · 2021Article
- Adventitial Cell Atlas of wt (Wild Type) and ApoE (Apolipoprotein E)-Deficient Mice Defined by Single-Cell RNA Sequencing.Arteriosclerosis, thrombosis, and vascular biology · 2019Article
- Unsupervised, Statistically Based Systems Biology Approach for Unraveling the Genetics of Complex Traits: A Demonstration with Ethanol Metabolism.Alcoholism, clinical and experimental research · 2018Article
- Review
- HDL and atherosclerotic cardiovascular disease: genetic insights into complex biology.Nature reviews. Cardiology · 2018Review
- Placental transcriptome co-expression analysis reveals conserved regulatory programs across gestation.BMC genomics · 2017Article
- A Weighted SNP Correlation Network Method for Estimating Polygenic Risk Scores.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Genetic control of obesity, glucose homeostasis, dyslipidemia and fatty liver in a mouse model of diet-induced metabolic syndrome.International journal of obesity (2005) · 2016Article
- An Integrative Genomic Study Implicates the Postsynaptic Density in the Pathogenesis of Bipolar Disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- A Systems Approach Implicates a Brain Mitochondrial Oxidative Homeostasis Co-expression Network in Genetic Vulnerability to Alcohol Withdrawal.Frontiers in genetics · 2016Article
- Genes located in a chromosomal inversion are correlated with territorial song in white-throated sparrows.Genes, brain, and behavior · 2015Article
- Quantitative assessment of gene expression network module-validation methods.Scientific reports · 2015Article
- Multi-omic network signatures of disease.Frontiers in genetics · 2014Article
- Cell Type Specific Analysis of Human Brain Transcriptome Data to Predict Alterations in Cellular Composition.Systems biomedicine (Austin, Tex.) · 2013Article
- The systems genetics resource: a web application to mine global data for complex disease traits.Frontiers in genetics · 2013Article
- Article
- Using bioinformatics and systems genetics to dissect HDL-cholesterol genetics in an MRL/MpJ x SM/J intercross.Journal of lipid research · 2012Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
We report a systems genetic analysis of high density lipoprotein (HDL) levels in an F2 intercross between inbred strains CAST/EiJ and C57BL/6J. We previously showed that there are dramatic differences in HDL metabolism in a cross between these strains, and we now report co-expression network analysis of HDL that integrates global expression data from liver and adipose with relevant metabolic traits. Using data from a total of 293 F2 intercross mice, we constructed weighted gene co-expression networks and identified modules (subnetworks) associated with HDL and clinical traits. These were examined for genes implicated in HDL levels based on large human genome-wide associations studies (GWAS) and examined with respect to conservation between tissue and sexes in a total of 9 data sets. We identify genes that are consistently ranked high by association with HDL across the 9 data sets. We focus in particular on two genes, Wfdc2 and Hdac3, that are located in close proximity to HDL QTL peaks where causal testing indicates that they may affect HDL. Our results provide a rich resource for studies of complex metabolic interactions involving HDL. This article is part of a Special Issue entitled Advances in High Density Lipoprotein Formation and Metabolism: A Tribute to John F. Oram (1945-2010).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.