ArticleSchizophrenia research2012
Prolactin concentrations in newly diagnosed, antipsychotic-naïve patients with nonaffective psychosis.
Article in Schizophrenia research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sex Differences in Serum Prolactin Levels in Children and Adolescents on Antipsychotics: A Systematic Review and Meta-Analysis.Current neuropharmacology · 2023Pooled it
- Sex-specific prolactin disturbance and divergent gonadal hormone correlates in first-episode schizophrenia.The international journal of neuropsychopharmacology · 2025Article
- Is There a Link Between TSH Levels and Schizophrenia? A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Physical illness in schizophrenia and the role of tolerability in antipsychotic selection: an expert consensus with a focus on cariprazine.Annals of general psychiatry · 2025Review
- Psychotic symptoms in Chinese adolescent patients with major depressive disorder: prevalence and related endocrine clinical factors.BMC psychiatry · 2024Article
- Effect of Age, Gender, Food Intake, Obesity, and Smoking on Serum Levels of Prolactin in Healthy Adults.Journal of personalized medicine · 2024Article
- Neurobiochemical Disturbances in Psychosis and their Implications for Therapeutic Intervention.Current topics in medicinal chemistry · 2024Review
- Association of Prolactin, Oxytocin, and Homocysteine With the Clinical and Cognitive Features of a First Episode of Psychosis Over a 1-Year Follow-Up.The international journal of neuropsychopharmacology · 2023Article
- The Involvement of Prolactin in Stress-Related Disorders.International journal of environmental research and public health · 2023Review
- The Influence of Oxytocin and Prolactin During a First Episode of Psychosis: The Implication of Sex Differences, Clinical Features, and Cognitive Performance.The international journal of neuropsychopharmacology · 2022Article
- Crosstalk between Schizophrenia and Metabolic Syndrome: The Role of Oxytocinergic Dysfunction.International journal of molecular sciences · 2022Review
- Relationship Between Gonadal Hormone Levels and Symptom Severity in Female Patients With Schizophrenia.Alpha psychiatry · 2021Article
- Targeting Hormones for Improving Cognition in Major Mood Disorders and Schizophrenia: Thyroid Hormones and Prolactin.Clinical drug investigation · 2020Review
- Hyperprolactinemia and insulin resistance in drug naive patients with early onset first episode psychosis.BMC psychiatry · 2018Article
- Systemic Biomarkers of Accelerated Aging in Schizophrenia: A Critical Review and Future Directions.Schizophrenia bulletin · 2018Review
- Review of serum prolactin levels as an antipsychotic-response biomarker.Open access journal of translational medicine & research · 2018Article
- Current Data on and Clinical Insights into the Treatment of First Episode Nonaffective Psychosis: A Comprehensive Review.Neurology and therapy · 2016Review
- Dopamine-prolactin pathway potentially contributes to the schizophrenia and type 2 diabetes comorbidity.Translational psychiatry · 2016Review
- Hair cortisol in drug-naïve first-episode individuals with psychosis.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2016Article
- The search for new biomarkers for cognition in schizophrenia.Schizophrenia research. Cognition · 2015Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundPrevious studies have found increased prolactin concentrations in antipsychotic-naïve patients with schizophrenia. However, the roles of other hormones, and of potentially confounding variables such as gender and smoking, have not been considered.
methodsBlood from newly diagnosed, antipsychotic-naïve patients with nonaffective psychosis (13 women and 20 men) and matched controls (12 women and 21 men) was assayed for prolactin, as well as three other hormones that impact prolactin concentrations: thyrotropin-stimulating hormone (TSH), ghrelin, and cortisol.
resultsPatients had significantly higher prolactin concentrations: female patients had a mean [SD] of 37.1 ng/mL [24.9] vs. 13.5 ng/mL [7.2] for female control subjects (p=.001), while male patients had a mean of 15.3 ng/mL [9.5] vs. 7.6 ng/mL [2.2] for male control subjects (p=.006). Patients and control subjects did not differ on concentrations of TSH, ghrelin, or cortisol. The group differences could not be attributed to differences in age, gender, smoking, body mass index, ethnicity, or the socioeconomic status of the family of origin.
conclusionsIncreased prolactin concentrations in antipsychotic-naïve patients do not appear to be due to important confounding variables, or to the effects of elevated TSH, ghrelin, or cortisol.
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Registered trials
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