ArticleJournal of chromatography. B, Analytical technologies in the biomedical and life sciences2011
Quantitative analysis of myo-inositol in urine, blood and nutritional supplements by high-performance liquid chromatography tandem mass spectrometry.
Article in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Inositol for the prevention of neural tube defects: a pilot randomised controlled trial.The British journal of nutrition · 2016Trial
- A culturomics approach reveals cross-feeding capacity of intestinal pig bacteria upon release of inositol from phytate.Microbiome · 2026Article
- A Compact 2-D photonic crystal biomedical sensor for enhanced glucose concentration detection in urine.Scientific reports · 2025Article
- Effects of primary calcium source on phytase efficiency in weaned piglets.Journal of animal science · 2025Article
- Phytase Improves Zinc Utilization by Broiler Chickens.Animals : an open access journal from MDPI · 2024Article
- Investigating Genetic Determinants of Plasma Inositol Status in Adult Humans.The Journal of nutrition · 2022Article
- A myo-inositol bioassay utilizing an auxotrophic strain of S. cerevisiae.Journal of microbiological methods · 2021Article
- Inositols: From Established Knowledge to Novel Approaches.International journal of molecular sciences · 2021Review
- Inositols Depletion and Resistance: Principal Mechanisms and Therapeutic Strategies.International journal of molecular sciences · 2021Review
- High doses of phytase on growth performance, bone mineralization, diet utilization, and plasmatic myo-inositol of turkey poults.Poultry science · 2021Article
- Effect of different doses of phytase and protein content of soybean meal on growth performance, nutrient digestibility, and bone characteristics of broilers.Poultry science · 2021Article
- Article
- PCOS and Inositols: Controversial Results and Necessary Clarifications. Basic Differences Between D-Chiro and Myo-Inositol.Frontiers in endocrinology · 2021Article
- Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry.Nature communications · 2020Article
- Monitoring Phytate Hydrolysis Using Serial Blood Sampling and Feather Myo-Inositol Levels in Broilers.Frontiers in physiology · 2020Article
- Inositol Treatment for PCOS Should Be Science-Based and Not Arbitrary.International journal of endocrinology · 2020Review
- Extra-phosphoric effects of super dosing phytase on growth performance of pigs is not solely due to release of myo-inositol.Journal of animal science · 2019Article
- Metabolomic studies as a tool for determining the post-mortem interval (PMI) in stillborn calves.BMC veterinary research · 2019Article
- Inositol, neural tube closure and the prevention of neural tube defects.Birth defects research · 2017Review
- Putative role of the H(+)/sucrose symporter SLC45A3 as an osmolyte transporter in the kidney.Pflugers Archiv : European journal of physiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Myo-inositol plays key physiological functions, necessitating development of methodology for quantification in biological matrices. Limitations of current mass spectrometry-based approaches include the need for a derivatisation step and/or sample clean-up. In addition, co-elution of glucose may cause ion suppression of myo-inositol signals, for example in blood or urine samples. We describe an HPLC-MS/MS method using a lead-form resin based column online to a triple quadrupole tandem mass spectrometer, which requires minimum sample preparation and no derivatisation. This method allows separation and selective detection of myo-inositol from other inositol stereoisomers. Importantly, inositol was also separated from hexose monosaccharides of the same molecular weight, including glucose, galactose, mannose and fructose. The inter- and intra-assay variability was determined for standard solutions and urine with inter-assay coefficient of variation (CV) of 1.1% and 3.5% respectively, while intra-assay CV was 2.3% and 3.6%. Urine and blood samples from normal individuals were analysed.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.